Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

Y. Krishna Reddy, L. Manmohan Reddy, Jorge H. Capdevila, J R Falck

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.

Original languageEnglish (US)
Pages (from-to)3719-3720
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number21
DOIs
StatePublished - Nov 3 2003

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Ether
Neutrophils
Acids
16-hydroxy-5,8,11,14-eicosatetraenoic acid
glycidyl ethers

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity. / Reddy, Y. Krishna; Reddy, L. Manmohan; Capdevila, Jorge H.; Falck, J R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 21, 03.11.2003, p. 3719-3720.

Research output: Contribution to journalArticle

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AU - Falck, J R

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