Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

Y. Krishna Reddy, L. Manmohan Reddy, Jorge H. Capdevila, J R Falck

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.

Original languageEnglish (US)
Pages (from-to)3719-3720
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number21
DOIs
StatePublished - Nov 3 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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