Practical olefin hydroamination with nitroarenes

Jinghan Gui, Chung Mao Pan, Ying Jin, Tian Qin, Julian C. Lo, Bryan J. Lee, Steven H. Spergel, Michael E. Mertzman, William J. Pitts, Thomas E. La Cruz, Michael A. Schmidt, Nitin Darvatkar, Swaminathan R. Natarajan, Phil S. Baran

Research output: Contribution to journalArticle

190 Scopus citations

Abstract

The synthesis and functionalization of amines are fundamentally important in a vast range of chemical contexts. We present an amine synthesis that repurposes two simple feedstock building blocks: olefins and nitro(hetero)arenes. Using readily available reactants in an operationally simple procedure, the protocol smoothly yields secondary amines in a formal olefin hydroamination. Because of the presumed radical nature of the process, hindered amines can easily be accessed in a highly chemoselective transformation. A screen of more than 100 substrate combinations showcases tolerance of numerous unprotected functional groups such as alcohols, amines, and even boronic acids. This process is orthogonal to other aryl amine syntheses, such as the Buchwald-Hartwig, Ullmann, and classical amine-carbonyl reductive aminations, as it tolerates aryl halides and carbonyl compounds.

Original languageEnglish (US)
Pages (from-to)886-891
Number of pages6
JournalScience
Volume348
Issue number6237
DOIs
StatePublished - May 22 2015
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Gui, J., Pan, C. M., Jin, Y., Qin, T., Lo, J. C., Lee, B. J., Spergel, S. H., Mertzman, M. E., Pitts, W. J., La Cruz, T. E., Schmidt, M. A., Darvatkar, N., Natarajan, S. R., & Baran, P. S. (2015). Practical olefin hydroamination with nitroarenes. Science, 348(6237), 886-891. https://doi.org/10.1126/science.aab0245