Pre-existing hypercoagulability in patients undergoing potentially curative cancer resection

Chad M. Thorson, Robert M. Van Haren, Mark L. Ryan, Emiliano Curia, Danny Sleeman, Joe U. Levi, Alan S. Livingstone, Kenneth G. Proctor

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background. Rotational thromboelastometry (ROTEM) is a new point-of-care test that allows a rapid and comprehensive evaluation of coagulation. We were among the first to show that ROTEM identifies baseline hypercoagulability in 40% of patients with intra-abdominal malignancies and that hypercoagulability persists for ≥1 month after resection. The purpose of this follow-up study was to confirm and extend these observations to a larger population in outpatient preoperative clinics. The hypothesis is that pre-existing hypercoagulability is present in patients undergoing surgery for malignant disease and that coagulation status varies by tumor type. Methods. After informed consent, preoperative blood samples were drawn from patients undergoing exploratory laparotomies for intra-abdominal malignancies and analyzed with ROTEM. Results. Eighty-two patients were enrolled, including 72 with a confirmed pathologic diagnosis and 10 age-matched controls with benign disease. The most common cancers involved the pancreas (n = 23; 32%), esophagus (n = 19; 26%), liver (n = 12; 17%), stomach (n = 7; 10%), and bile ducts (n = 5; 7%). Preoperative hypercoagulability was detected in 31% (n = 22); these patients were more likely to have lymphovascular invasion (88% vs 50%; P = .011), perineural invasion (77% vs 36%; P = .007), and stage III/IV disease (80% vs 62%; P = .039). More patients with pancreatic tumors (9/23, 39%) were hypercoagulable than with esophageal (3/19, 16%) or liver (2/13, 15%, P = .034) tumors. When only resectable malignancies were considered, clot formation was more rapid (low clot formation time, high alpha) with enhanced maximum clot strength (high maximum clot firmness) in pancreatic versus esophageal or liver cancers and in all cancers versus those with benign disease. Conclusion. Preoperative hypercoagulability can be identified with ROTEM and is associated with lymphovascular/perineural invasion and advanced-staged disease in cancer. Compared with other tumor types, pancreatic adenocarcinomas have the greatest risk for hypercoagulability.

Original languageEnglish (US)
Pages (from-to)134-144
Number of pages11
JournalSurgery (United States)
Volume155
Issue number1
DOIs
Publication statusPublished - Jan 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

Cite this

Thorson, C. M., Van Haren, R. M., Ryan, M. L., Curia, E., Sleeman, D., Levi, J. U., ... Proctor, K. G. (2014). Pre-existing hypercoagulability in patients undergoing potentially curative cancer resection. Surgery (United States), 155(1), 134-144. https://doi.org/10.1016/j.surg.2013.06.053