Pre-ischemic treatment with ampicillin reduces neuronal damage in the mouse hippocampus and neostriatum after transient forebrain ischemia

Kyung Eon Lee, Seul Ki Kim, Kyung Ok Cho, Seong Yun Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Ampicillin, a β-lactam antibiotic, has been reported to induce astrocytic glutamate transporter-1 which plays a crucial role in protecting neurons against glutamate excitotoxicity. We investigated the effect of ampicillin on neuronal damage in the mouse hippocampus and neostriatum following transient global forebrain ischemia. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral occlusion of the common carotid artery for 40 min. Ampicillin was administered post-ischemically (for 3 days) and/or pre-ischemically (for 3-5 days until one day before the onset of ischemia). Pre- and post-ischemic treatment with ampicillin (50 mg/kg/day or 200 mg/kg/day) prevented ischemic neuronal death in the medial CA1 area of the hippocampus as well as the neostriatum in a dose-dependent manner. In addition, ischemic neuronal damage was reduced by pre-ischemic treatment with ampicillin (200 mg/kg/day). In summary, our results suggest that ampicillin plays a functional role as a chemical preconditioning agent that protects hippocampal neurons from ischemic insult.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalKorean Journal of Physiology and Pharmacology
Volume12
Issue number6
DOIs
StatePublished - Dec 2008

Keywords

  • Ampicillin
  • Global forebrain ischemia
  • Hippocampus
  • Mice
  • Neostriatum
  • Neuroprotection

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

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