@article{087dcb28dba840a4a0802542f9819ad5,
title = "Precision editing of the gut microbiota ameliorates colitis",
abstract = "Inflammatory diseases of the gastrointestinal tract are frequently associated with dysbiosis, characterized by changes in gut microbial communities that include an expansion of facultative anaerobic bacteria of the Enterobacteriaceae family (phylum Proteobacteria). Here we show that a dysbiotic expansion of Enterobacteriaceae during gut inflammation could be prevented by tungstate treatment, which selectively inhibited molybdenum-cofactor-dependent microbial respiratory pathways that are operational only during episodes of inflammation. By contrast, we found that tungstate treatment caused minimal changes in the microbiota composition under homeostatic conditions. Notably, tungstate-mediated microbiota editing reduced the severity of intestinal inflammation in mouse models of colitis. We conclude that precision editing of the microbiota composition by tungstate treatment ameliorates the adverse effects of dysbiosis in the inflamed gut.",
author = "Wenhan Zhu and Winter, {Maria G.} and Byndloss, {Mariana X.} and Luisella Spiga and Duerkop, {Breck A.} and Hughes, {Elizabeth R.} and Lisa B{\"u}ttner and {De Lima Rom{\~a}o}, Everton and Behrendt, {Cassie L.} and Lopez, {Christopher A.} and Luis Sifuentes-Dominguez and Kayci Huff-Hardy and Wilson, {R. Paul} and Gillis, {Caroline C.} and {\c C}agla T{\"u}kel and Koh, {Andrew Y.} and Ezra Burstein and Hooper, {Lora V.} and B{\"a}umler, {Andreas J.} and Winter, {Sebastian E.}",
note = "Funding Information: Acknowledgements This work was supported by NIH grants AI112445 (A.J.B.), AI118807 (S.E.W.), AI128151 (S.E.W.), DK070855 (L.V.H.), DK102436 (B.A.D.) and 5K12HD-068369 (L.S.-D.), Welch Foundation grants I-1858 (S.E.W.) and I-1874 (L.V.H.), American Cancer Society Research Scholar Grant MPC-130347 (S.E.W.) and a Crohn{\textquoteright}s and Colitis Foundation of America postdoctoral fellowship no. 454921 (W.Z.). Work in the L.V.H. laboratory is supported by the Howard Hughes Medical Institute. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the funders. We thank B. Sartor for the E. coli NC101 strain. Publisher Copyright: {\textcopyright} 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",
year = "2018",
month = jan,
day = "11",
doi = "10.1038/nature25172",
language = "English (US)",
volume = "553",
pages = "208--211",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7687",
}