Precision Medicine and PET/Computed Tomography in Melanoma

Esther Mena, Yasemin Sanli, Charles Marcus, Rathan M. Subramaniam

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Recent advances in genomic profiling and sequencing of melanoma have provided new insights into the development of the basis for molecular biology to more accurately subgroup patients with melanoma. The development of novel mutation-targeted and immunomodulation therapy as a major component of precision oncology has revolutionized the management and outcome of patients with metastatic melanoma. PET imaging plays an important role in noninvasively assessing the tumor biological behavior, to guide individualized treatment and assess response to therapy. This review summarizes the recent genomic discoveries in melanoma in the era of targeted therapy and their implications for functional PET imaging.

Original languageEnglish (US)
Pages (from-to)449-458
Number of pages10
JournalPET Clinics
Volume12
Issue number4
DOIs
StatePublished - Oct 1 2017

Keywords

  • Biomarker
  • Immunotherapy
  • Melanoma
  • Molecular imaging
  • Precision oncology
  • Targeted therapy

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Mena, E., Sanli, Y., Marcus, C., & Subramaniam, R. M. (2017). Precision Medicine and PET/Computed Tomography in Melanoma. PET Clinics, 12(4), 449-458. https://doi.org/10.1016/j.cpet.2017.05.002