Precision Medicine in the Management of Drug Allergy

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of study: The term precision medicine has been developed in the last five or more years to describe the concept of treating patients individually based on a variety of factors. Precision medicine can be applied to the field of drug allergy where phenotypes, endotypes, and biomarkers have been defined. Recent findings: Phenotypes of drug allergy can be based on (1) the mechanism of the underlying reaction; (2) the clinical presentation of the reaction; and (3) the timing of the reaction in regards to exposure to the drug. Endotypes of drug allergy can be defined based on mechanisms, pharmacologic processes, and human leukocyte antigen haplotypes. Lastly, biomarkers utilized in drug allergy include skin tests, specific IgE tests, basophil activation tests, cellular-based assays, mediator measurement, drug patch tests, and genotyping. The approach to penicillin allergy in recent years highlights the application of precision medicine in drug allergy.

Original languageEnglish (US)
Pages (from-to)60-73
Number of pages14
JournalCurrent Treatment Options in Allergy
Volume5
Issue number1
DOIs
StatePublished - Mar 2018

Keywords

  • Biomarker
  • Drug allergy
  • Endotype
  • Hypersensitivity
  • Penicillin allergy
  • Phenotype
  • Precision medicine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Medicine (miscellaneous)

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