Precocious puberty following severe head trauma

P. W. Shaul, R. B. Towbin, S. D. Chernausek

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

True precocious puberty is frequently secondary to intrinsic central nervous system pathology, but is rare following external head trauma. We describe two children who developed precocious puberty within three months of severe exogenous head trauma. Infusion of luteinizing hormone releasing factor induced a prompt rise in circulating gonadotropin concentrations and established that their sexual precocity was the result of premature activation of the hypothalamic-pituitary axis. While the precise mechanism by which exogenous head trauma causes precocious puberty remains unknown, the clinical features of these children's disorders are consistent with the hypothesis that extrahypothalamic areas restrain pituitary gonadotropin secretion before puberty and that damage to these areas can result in precocious puberty.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume139
Issue number5
StatePublished - 1985

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Precocious Puberty
Craniocerebral Trauma
Pituitary Gonadotropins
Puberty
Luteinizing Hormone
Gonadotropins
Central Nervous System
Pathology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Shaul, P. W., Towbin, R. B., & Chernausek, S. D. (1985). Precocious puberty following severe head trauma. American Journal of Diseases of Children, 139(5), 467-469.

Precocious puberty following severe head trauma. / Shaul, P. W.; Towbin, R. B.; Chernausek, S. D.

In: American Journal of Diseases of Children, Vol. 139, No. 5, 1985, p. 467-469.

Research output: Contribution to journalArticle

Shaul, PW, Towbin, RB & Chernausek, SD 1985, 'Precocious puberty following severe head trauma', American Journal of Diseases of Children, vol. 139, no. 5, pp. 467-469.
Shaul, P. W. ; Towbin, R. B. ; Chernausek, S. D. / Precocious puberty following severe head trauma. In: American Journal of Diseases of Children. 1985 ; Vol. 139, No. 5. pp. 467-469.
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