Precycle administration of GnRH antagonist and microdose HCG decrease clinical pregnancy rates without affecting embryo quality and blastulation

Orhan Bukulmez, Khurram S. Rehman, Martin Langley, Bruce R. Carr, Anna C. Nackley, Kathleen M. Doody, Kevin J. Doody

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The outcome of a novel protocol utilizing precycle gonadotrophin-releasing hormone (GnRH) antagonist administration and LH activity support with microdose recombinant human chorionic gonadotrophin (HCG) was compared to GnRH agonist long protocol used in patients undergoing their first ICSI (n = 707) or IVF (n = 571) cycles, which had resulted in one or two blastocyst transfers. In GnRH antagonist cycles, cetrorelix acetate (3 mg) was administered s.c. 4 days before FSH stimulation and a repeat dose was given when the lead follicular diameter was 13-14 mm. LH support was provided by recombinant HCG (2.5 μg). Embryo progression and blastulation were evaluated using embryo progression indices and blastocyst quality scores. The tested protocol demonstrated reduced implantation and clinical pregnancy rates as compared with GnRH agonist long protocol, although the embryo progression and blastulation parameters and blastocyst quality were comparable among the groups. Logistic regression models further supported the significant negative impact of GnRH antagonist/microdose HCG protocol on clinical pregnancy rates in both ICSI and IVF patients. Assisted reproduction cycles with fresh blastocyst transfers utilizing precycle GnRH antagonist administration and microdose HCG support resulted in lower implantation and clinical pregnancy rates as compared with GnRH agonist cycles, although the embryo progression and blastulation parameters were comparable.

Original languageEnglish (US)
Article number2396
Pages (from-to)465-475
Number of pages11
JournalReproductive BioMedicine Online
Volume13
Issue number4
DOIs
StatePublished - Oct 2006

Keywords

  • Assisted reproduction
  • Clinical pregnancy
  • GnRH agonist
  • GnRH antagonist
  • Implantation
  • Microdose HCG

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Precycle administration of GnRH antagonist and microdose HCG decrease clinical pregnancy rates without affecting embryo quality and blastulation'. Together they form a unique fingerprint.

Cite this