Predicting Cardiovascular Risk in Type 2 Diabetes: the Heterogeneity Challenges

M. Odette Gore, Darren K McGuire, Ildiko Lingvay, Julio Rosenstock

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Type 2 diabetes mellitus has reached epidemic proportions around the world, and the increase in cardiovascular risk attributable to diabetes estimated to range from 2- to 4-fold poses grave public health concern. Though in some contexts type 2 diabetes has been equated with coronary heart disease equivalent risk, there is considerable evidence that incremental cardiovascular risk does not uniformly affect all people with type 2 diabetes. This heterogeneity in cardiovascular risk is multifactorial and only partially understood but is a key consideration for our understanding of the nexus of diabetes and cardiovascular disease and for the development of optimal and individualized cardiovascular risk reduction strategies. This review provides a brief synopsis of the concept of cardiovascular risk heterogeneity in diabetes, including epidemiologic evidence, discussion of established and potential determinants of heterogeneity, and clinical, research, and regulatory implications.

Original languageEnglish (US)
Article number54
JournalCurrent Cardiology Reports
Issue number7
StatePublished - Jul 4 2015


  • Cardiovascular disease
  • Cardiovascular risk factors
  • Diabetes mellitus
  • Macrovascular complications

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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