TY - JOUR
T1 - Predicting short-term mortality and long-term survival for hospitalized US patients with alcoholic hepatitis
AU - Cuthbert, Jennifer A.
AU - Arslanlar, Sami
AU - Yepuri, Jay
AU - Montrose, Marc
AU - Ahn, Chul W.
AU - Shah, Jessica P.
N1 - Funding Information:
Acknowledgments The authors are indebted to Dwain Thiele, M.D. for questioning the validity of the discriminant function in an era of changing prothrombin reagents, for deriving the equation comparing results before and after, and for working with members of the coagulation laboratory at Parkland Health and Hospital System to validate the relationship by comparing [1,000 results in tandem. This study was supported in part by NIH U01-AA021893.
PY - 2014/4
Y1 - 2014/4
N2 - Background: No study has evaluated current scoring systems for their accuracy in predicting short and long-term outcome of alcoholic hepatitis in a US population. Methods: We reviewed electronic records for patients with alcoholic liver disease (ALD) admitted to Parkland Memorial Hospital between January 2002 and August 2005. Data and outcomes for 148 of 1,761 admissions meeting pre-defined criteria were collected. The discriminant function (DF) was revised (INRdf) to account for changes in prothrombin time reagents that could potentially affect identification of risk using the previous DF threshold of >32. Admission and theoretical peak scores were calculated by use of the Model for End-stage Liver Disease (MELD). Analysis models compared five different scoring systems. Results: INRdf was closely correlated with the old DF (r 2 = 0.95). Multivariate analysis of the data showed that survival for 28 days was significantly associated with a scoring system using a combination of age, bilirubin, coagulation status, and creatinine (p < 0.001), and an elevated ammonia result within two days of admission (p = 0.012). When peak values for MELD were included, they were the most significant predictor of short-term mortality (p < 0.001), followed by INRdf (p = 0.006). Conclusion: On admission, two scoring systems that identify a subset of patients with severe alcoholic liver disease are able to predict >50 % mortality at four weeks and >80 % mortality at six months without specific treatment.
AB - Background: No study has evaluated current scoring systems for their accuracy in predicting short and long-term outcome of alcoholic hepatitis in a US population. Methods: We reviewed electronic records for patients with alcoholic liver disease (ALD) admitted to Parkland Memorial Hospital between January 2002 and August 2005. Data and outcomes for 148 of 1,761 admissions meeting pre-defined criteria were collected. The discriminant function (DF) was revised (INRdf) to account for changes in prothrombin time reagents that could potentially affect identification of risk using the previous DF threshold of >32. Admission and theoretical peak scores were calculated by use of the Model for End-stage Liver Disease (MELD). Analysis models compared five different scoring systems. Results: INRdf was closely correlated with the old DF (r 2 = 0.95). Multivariate analysis of the data showed that survival for 28 days was significantly associated with a scoring system using a combination of age, bilirubin, coagulation status, and creatinine (p < 0.001), and an elevated ammonia result within two days of admission (p = 0.012). When peak values for MELD were included, they were the most significant predictor of short-term mortality (p < 0.001), followed by INRdf (p = 0.006). Conclusion: On admission, two scoring systems that identify a subset of patients with severe alcoholic liver disease are able to predict >50 % mortality at four weeks and >80 % mortality at six months without specific treatment.
KW - Alcoholic hepatitis scores
KW - Discriminant function
KW - Internal sensitivity index
KW - Model of End-stage Liver Disease
KW - Prothrombin time
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U2 - 10.1007/s10620-013-3020-3
DO - 10.1007/s10620-013-3020-3
M3 - Article
C2 - 24445730
AN - SCOPUS:84903517609
SN - 0163-2116
VL - 59
SP - 1594
EP - 1602
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 7
ER -