Prediction of early kidney transplant rejection by a crossmatch with donor skin

J. R. Moraes, C. Pettaway, P. Stastny

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Immunofluorescence staining of donor skin with recipient serum was performed in 25 patients undergoing kidney transplantation. Transplants were performed when cytotoxicity T cell crossmatches with long incubation and with antiglobulin enhancement were negative. In 20 patients the skin crossmatch was negative and all had an uneventful course. In 5 other recipients, the crossmatch with skin was positive and all developed severe rejection 1—8 days after transplantation. The correlation between skin crossmatch and early rejection was statistically highly significant (P<0.00001). Rejection in the skin-crossmatch—positive group led to graft loss in 3, and chronic rejection with poor residual function in the other 2 patients. Serum creatinine at one month was in the 2.6—5.0 mg/dl range in these two patients, while in the group with negative skin crossmatches 15 had serum creatinine levels of less than 1.6, and 5 were in the 1.6-2.5 mg/dl range. Although the nature of the skin antigen is unknown, it appears that this crossmatch procedure was highly accurate in predicting early kidney transplant rejection.

Original languageEnglish (US)
Pages (from-to)951-952
Number of pages2
JournalTransplantation
Volume48
Issue number6
DOIs
StatePublished - Dec 1989

ASJC Scopus subject areas

  • Transplantation

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