Prediction of individual progression rate in parkinson's disease using clinical measures and biomechanical measures of gait and postural stability

Vyom Raval, Kevin P. Nguyen, Ashley Gerald, Richard B. Dewey, Albert Montillo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Parkinson's disease (PD) is a common neurological disorder characterized by gait impairment. PD has no cure, and an impediment to developing a treatment is the lack of any accepted method to predict disease progression rate. The primary aim of this study was to develop a model using clinical measures and biomechanical measures of gait and postural stability to predict an individual's PD progression over two years. Data from 160 PD subjects were utilized. Machine learning models, including XGBoost and Feed Forward Neural Networks, were developed using extensive model optimization and cross-validation. The highest performing model was a neural network that used a group of clinical measures, achieved a PPV of 71% in identifying fast progressors, and explained a large portion (37%) of the variance in an individual's progression rate on held-out test data. This demonstrates the potential to predict individual PD progression rate and enrich trials by analyzing clinical and biomechanical measures with machine learning.

Original languageEnglish (US)
Title of host publication2020 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2020 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1319-1323
Number of pages5
ISBN (Electronic)9781509066315
DOIs
StatePublished - May 2020
Event2020 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2020 - Barcelona, Spain
Duration: May 4 2020May 8 2020

Publication series

NameICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
Volume2020-May
ISSN (Print)1520-6149

Conference

Conference2020 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2020
CountrySpain
CityBarcelona
Period5/4/205/8/20

Keywords

  • Biomechanical Measures
  • Machine Learning
  • Parkinson's Disease
  • Prognosis
  • Progression Rate

ASJC Scopus subject areas

  • Software
  • Signal Processing
  • Electrical and Electronic Engineering

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