TY - JOUR
T1 - Prediction of response of chronic depression to imipramine
AU - Kocsis, James H.
AU - Mason, Barbara J.
AU - Frances, Allen J.
AU - Sweeney, John
AU - Mann, J. John
AU - Marin, Deborah
PY - 1989
Y1 - 1989
N2 - We had previously reported that imipramine was superior to placebo for the treatment of chronic depression. As a part of that study, we subsequently investigated clinical and demographic variables which might be associated with favorable or poor outcome for treatment with imipramine or placebo. Results are reported herein. Eighty-six patients were entered and 53 completed an 8-week protocol. Outcome was assessed based on a 6-week, double-blind treatment phase, which followed a 2-week, single-blind placebo phase. Outcome was not found to significantly relate to demographic variables, severity or course of depression, diagnostic subtype, symptom profile, or DST results. Some modest associations were found between 'neurotic' personality traits and poor outcome. Results are discussed and compared with prior studies of prediction of tricyclic antidepressant response in both acute and chronic depressions.
AB - We had previously reported that imipramine was superior to placebo for the treatment of chronic depression. As a part of that study, we subsequently investigated clinical and demographic variables which might be associated with favorable or poor outcome for treatment with imipramine or placebo. Results are reported herein. Eighty-six patients were entered and 53 completed an 8-week protocol. Outcome was assessed based on a 6-week, double-blind treatment phase, which followed a 2-week, single-blind placebo phase. Outcome was not found to significantly relate to demographic variables, severity or course of depression, diagnostic subtype, symptom profile, or DST results. Some modest associations were found between 'neurotic' personality traits and poor outcome. Results are discussed and compared with prior studies of prediction of tricyclic antidepressant response in both acute and chronic depressions.
KW - Depression
KW - Dysthymia
KW - Tricyclic antidepressant
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U2 - 10.1016/0165-0327(89)90008-6
DO - 10.1016/0165-0327(89)90008-6
M3 - Article
C2 - 2529294
AN - SCOPUS:0024395405
SN - 0165-0327
VL - 17
SP - 255
EP - 260
JO - Journal of affective disorders
JF - Journal of affective disorders
IS - 3
ER -