Predictive chromatin signatures in the mammalian genome

Gary C. Hon, R. David Hawkins, Bing Ren

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

The DNA sequence of an organism is a blueprint of life: it harbors not only the information about proteins and other molecules produced in each cell, but also instructions on when and where such molecules are made. Chromatin, the structure of histone and DNA that has co-evolved with eukaryotic genome, also contains information that indicates the function and activity of the underlying DNA sequences. Such information exists in the form of covalent modifications to the histone proteins that comprise the nucleosome. Thanks to the development of high throughput technologies such as DNA microarrays and next generation DNA sequencing, we have begun to associate the various combinations of chromatin modification patterns with functional sequences in the human genome. Here, we review the rapid progress from descriptive observations of histone modification profiles to highly predictive models enabling use of chromatin signatures to enumerate novel functional sequences in mammalian genomes that have escaped previous detection.

Original languageEnglish (US)
JournalHuman Molecular Genetics
Volume18
Issue numberR2
DOIs
StatePublished - Oct 15 2009

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Histone Code
Chromatin
Genome
Nucleosomes
Human Genome
Oligonucleotide Array Sequence Analysis
DNA Sequence Analysis
Histones
Proteins
Technology
DNA

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

Predictive chromatin signatures in the mammalian genome. / Hon, Gary C.; Hawkins, R. David; Ren, Bing.

In: Human Molecular Genetics, Vol. 18, No. R2, 15.10.2009.

Research output: Contribution to journalArticle

Hon, Gary C. ; Hawkins, R. David ; Ren, Bing. / Predictive chromatin signatures in the mammalian genome. In: Human Molecular Genetics. 2009 ; Vol. 18, No. R2.
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