Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia

Victor M. Aquino, Carrye Cost, Ana Gomez, Daniel C. Bowers, Octavio Ramilo, Naveed Ahmad, Naomi Winick, Patrick J. Leavey

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A variety of clinical and laboratory parameters have been used to predict bacteremia. We hypothesize that the generation of a cytokine profile could be used to identify patients at higher risk of bacteremia at the time of presentation with febrile neutropenia. We prospectively evaluated children with cancer who presented with an episode of febrile neutropenia. A multiplexed flow cytometric assay was performed which measured 15 cytokines and chemokines obtained before the initiation of antibiotics. Fifty-eight episodes of chemotherapy-induced febrile neutropenia were included in this study during which 4 patients (7%) had bacteremia. An interleukin-5 level of >8 pg/dL had a sensitivity of 67% and a specificity of 96% to predict bacteremia. An monocyte chemotactic protein-1 level >1650 pg/dL had a sensitivity of 80% and a specificity of 82% to predict bacteremia. Erythrocyte sedimentation rate, C-reactive protein, protein C, and other cytokines/chemokines were not predictive of bacteremia. Elevations of interleukin-5 and monocyte chemotactic protein-1 are predictive of bacteremia in children with cancer who have febrile neutropenia. Prospective studies should be undertaken to determine whether these parameters retain predictive value in a larger series of patients and can select children for outpatient management or early discharge.

Original languageEnglish (US)
JournalJournal of Pediatric Hematology/Oncology
Volume34
Issue number6
DOIs
StatePublished - Aug 2012

Fingerprint

Febrile Neutropenia
Chemokine CCL2
Interleukin-5
Bacteremia
Cytokines
Chemokines
Chemotherapy-Induced Febrile Neutropenia
Blood Sedimentation
Protein C
C-Reactive Protein
Neoplasms
Outpatients
Prospective Studies
Anti-Bacterial Agents

Keywords

  • fever
  • interleukin-5
  • neutropenia
  • oncology
  • pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

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title = "Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia",
abstract = "A variety of clinical and laboratory parameters have been used to predict bacteremia. We hypothesize that the generation of a cytokine profile could be used to identify patients at higher risk of bacteremia at the time of presentation with febrile neutropenia. We prospectively evaluated children with cancer who presented with an episode of febrile neutropenia. A multiplexed flow cytometric assay was performed which measured 15 cytokines and chemokines obtained before the initiation of antibiotics. Fifty-eight episodes of chemotherapy-induced febrile neutropenia were included in this study during which 4 patients (7{\%}) had bacteremia. An interleukin-5 level of >8 pg/dL had a sensitivity of 67{\%} and a specificity of 96{\%} to predict bacteremia. An monocyte chemotactic protein-1 level >1650 pg/dL had a sensitivity of 80{\%} and a specificity of 82{\%} to predict bacteremia. Erythrocyte sedimentation rate, C-reactive protein, protein C, and other cytokines/chemokines were not predictive of bacteremia. Elevations of interleukin-5 and monocyte chemotactic protein-1 are predictive of bacteremia in children with cancer who have febrile neutropenia. Prospective studies should be undertaken to determine whether these parameters retain predictive value in a larger series of patients and can select children for outpatient management or early discharge.",
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T1 - Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia

AU - Aquino, Victor M.

AU - Cost, Carrye

AU - Gomez, Ana

AU - Bowers, Daniel C.

AU - Ramilo, Octavio

AU - Ahmad, Naveed

AU - Winick, Naomi

AU - Leavey, Patrick J.

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