Predictive value of post-procedural early (within 24 h) increase in cystatin C for contrast-induced acute kidney injury and mortality following coronary angiography or intervention

Yong Liu, Kai Hong Chen, Shi Qun Chen, Li Ling Chen, Chong Yang Duan, Kun Wang, Xiao Sheng Guo, Hua Long Li, Wei Jie Bei, Kai Yan Lin, Ping Yan Chen, Ying Xian, Ning Tan, Ying Ling Zhou, Qing Shan Geng, Ji Yan Chen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: To investigate the predictive value of post-procedural early (within 24 h) increase in cystatin C for contrast-induced acute kidney injury (CI-AKI) and all-cause mortality following coronary angiography or intervention. Methods: We prospectively investigated 1042 consecutive patients with both baseline and early post-procedural cystatin C measurement undergoing coronary angiography or intervention. CI-AKI was defined as an increase ≥0.3 mg/dL or > 50% in serum creatinine from baseline within 48 h post-procedure. Mean follow-up was 2.26 years. Results: Overall, the patients had a CI-AKI incidence was 3.6% (38/1042), mean serum creatinine of 87 μmol/L. Compared with Mehran risk score, post-procedural early absolute increase (AUC: 0.584 vs. 0.706, P = 0.060) and relative increase (AUC: 0.585 vs. 0.706, P = 0.058) in cystatin C had poorer predictive value for CIAKI. According to multivariate analysis, post-procedural significant early increase (≥0.3 mg/dL or ≥10%) in cystatin C developed in 231 patients (22.2%), was not independent predictor of CI-AKI (adjusted OR: 1.23, 95% CI, 0.56-2.69, P = 0.612), and long-term mortality (adjusted HR: 0.90; P = 0.838). Conclusions: Our data suggested post-procedural early increase (within 24 h) in cystatin C was not effective for predicting CI-AKI or all-cause mortality following coronary angiography or intervention among patients at relative low risk of CI-AKI, the negative finding of poor predictive value should be further evaluated in larger multicenter trials.

Original languageEnglish (US)
Pages (from-to)109762-109771
Number of pages10
JournalOncotarget
Volume8
Issue number65
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Contrast-induced acute kidney injury
  • Coronary angiography
  • Cystatin C
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Oncology

Fingerprint

Dive into the research topics of 'Predictive value of post-procedural early (within 24 h) increase in cystatin C for contrast-induced acute kidney injury and mortality following coronary angiography or intervention'. Together they form a unique fingerprint.

Cite this