TY - JOUR
T1 - Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles
AU - Tan, Orkun
AU - Ha, Thoa
AU - Carr, Bruce R.
AU - Nakonezny, Paul
AU - Doody, Kathleen M.
AU - Doody, Kevin J.
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/9
Y1 - 2014/9
N2 - Purpose: To determine whether postwashed total progressively motile sperm count (TPMSC) obtained by CASA estimates could predict positive pregnancy test result in non-donor IUI cycles.Methods: Six thousand eight hundred and seventy one (6,871) IUI cycles with non-donor semen were retrospectively analyzed. Patient, cycle characteristics and prewashed and postwashed semen parameters were included in analysis. The main outcome measure was the positive pregnancy test result.Results: The pregnancy rate per cycle (PR/cycle) when postwashed TPMSC is between 0–0.5 million, 0.51–1 million, 1.01–5 million, 5.01–10 million and greater than 10 million were 8.1 % (42/520), 14.4 % (41/285), 16.1 % (237/1,469), 18.4 % (193/1,046) and 18.8 % (668/3,551) respectively. The predicted odd of positive pregnancy result is statistically significantly higher when TPMSC is >0.51 million compared to the TPMSC of <0.51 million (OR = 1.68, 95 % CI: 1.04–2.71). The predicted odd of positive pregnancy result is greatest when TPMSC is at least 5 million (OR = 2, 95 % CI: 1.38 to 2.9).Conclusion: TPMSC is an independent predictor of pregnancy test result and TPMSC of half million or greater is adequate to achieve statistically similar pregnancy test results after non-donor IUI cycles.
AB - Purpose: To determine whether postwashed total progressively motile sperm count (TPMSC) obtained by CASA estimates could predict positive pregnancy test result in non-donor IUI cycles.Methods: Six thousand eight hundred and seventy one (6,871) IUI cycles with non-donor semen were retrospectively analyzed. Patient, cycle characteristics and prewashed and postwashed semen parameters were included in analysis. The main outcome measure was the positive pregnancy test result.Results: The pregnancy rate per cycle (PR/cycle) when postwashed TPMSC is between 0–0.5 million, 0.51–1 million, 1.01–5 million, 5.01–10 million and greater than 10 million were 8.1 % (42/520), 14.4 % (41/285), 16.1 % (237/1,469), 18.4 % (193/1,046) and 18.8 % (668/3,551) respectively. The predicted odd of positive pregnancy result is statistically significantly higher when TPMSC is >0.51 million compared to the TPMSC of <0.51 million (OR = 1.68, 95 % CI: 1.04–2.71). The predicted odd of positive pregnancy result is greatest when TPMSC is at least 5 million (OR = 2, 95 % CI: 1.38 to 2.9).Conclusion: TPMSC is an independent predictor of pregnancy test result and TPMSC of half million or greater is adequate to achieve statistically similar pregnancy test results after non-donor IUI cycles.
KW - Computer assisted sperm analysis
KW - Intrauterine insemination
KW - Pregnancy
KW - Semen analysis
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U2 - 10.1007/s10815-014-0306-0
DO - 10.1007/s10815-014-0306-0
M3 - Article
C2 - 25106939
AN - SCOPUS:84930356145
SN - 1058-0468
VL - 31
SP - 1147
EP - 1153
JO - Journal of assisted reproduction and genetics
JF - Journal of assisted reproduction and genetics
IS - 9
ER -