Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry

Italo Linfante; Gail R. Walker; Alicia C. Castonguay; Guilherme Dabus; Amy K. Starosciak; Albert J. Yoo; Alex Abou-Chebl; Gavin W. Britz; Franklin A. Marden; Alexandria Alvarez; Rishi Gupta; Chun Huan J Sun; Coleman Martin; William E. Holloway; Nils Mueller-Kronast; Joey D. English; Tim W. Malisch; Hormozd Bozorgchami; Andrew Xavier; Ansaar T. Rai; Michael T. Froehler; Aamir Badruddin; Thanh N. Nguyen; M. Asif Taqi; Michael G. Abraham; Vallabh Janardhan; Hashem Shaltoni; Roberta Novakovic; Peng R. Chen; Ritesh Kaushal; Ashish Nanda; Mohammad A. Issa; Raul G. Nogueira; Osama O. Zaidat

doi:10.1161/STROKEAHA.115.009530

Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry

Italo Linfante, Gail R. Walker, Alicia C. Castonguay, Guilherme Dabus, Amy K. Starosciak, Albert J. Yoo, Alex Abou-Chebl, Gavin W. Britz, Franklin A. Marden, Alexandria Alvarez, Rishi Gupta, Chun Huan J Sun, Coleman Martin, William E. Holloway, Nils Mueller-Kronast, Joey D. English, Tim W. Malisch, Hormozd Bozorgchami, Andrew Xavier, Ansaar T. RaiMichael T. Froehler, Aamir Badruddin, Thanh N. Nguyen, M. Asif Taqi, Michael G. Abraham, Vallabh Janardhan, Hashem Shaltoni, Roberta Novakovic, Peng R. Chen, Ritesh Kaushal, Ashish Nanda, Mohammad A. Issa, Raul G. Nogueira, Osama O. Zaidat

Research output: Contribution to journal › Article

28 Scopus citations

Abstract

BACKGROUND AND PURPOSE: Failure to recanalize predicts mortality in acute ischemic stroke. In the North American Solitaire Acute Stroke registry, we investigated parameters associated with mortality in successfully recanalized patients.

METHODS: Logistic regression was used to evaluate baseline characteristics and recanalization parameters for association with 90-day mortality. A multivariable model was developed based on backward selection with retention criteria of P

RESULTS: Successfully recanalized patients had lower mortality (25.2% [59/234] versus 46.9% [38/81] P

CONCLUSIONS: Failure to recanalize and presence of symptomatic intracranial hemorrhage resulted in increased mortality. Despite successful recanalization, proximal occlusion, high National Institutes of Health Stroke Scale, and need for rescue therapy were predictors of mortality.

Original language	English (US)
Pages (from-to)	2305-2308
Number of pages	4
Journal	Stroke; a journal of cerebral circulation
Volume	46
Issue number	8
DOIs	https://doi.org/10.1161/STROKEAHA.115.009530
State	Published - Aug 1 2015

Keywords

carotid artery, internal
intracra
mortality
nial hemorrhages
stroke
thrombectomy

ASJC Scopus subject areas

Medicine(all)

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10.1161/STROKEAHA.115.009530

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Linfante, I., Walker, G. R., Castonguay, A. C., Dabus, G., Starosciak, A. K., Yoo, A. J., Abou-Chebl, A., Britz, G. W., Marden, F. A., Alvarez, A., Gupta, R., Sun, C. H. J., Martin, C., Holloway, W. E., Mueller-Kronast, N., English, J. D., Malisch, T. W., Bozorgchami, H., Xavier, A., ... Zaidat, O. O. (2015). Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry. Stroke; a journal of cerebral circulation, 46(8), 2305-2308. https://doi.org/10.1161/STROKEAHA.115.009530

Predictors of Mortality in Acute Ischemic Stroke Intervention : Analysis of the North American Solitaire Acute Stroke Registry. / Linfante, Italo; Walker, Gail R.; Castonguay, Alicia C.; Dabus, Guilherme; Starosciak, Amy K.; Yoo, Albert J.; Abou-Chebl, Alex; Britz, Gavin W.; Marden, Franklin A.; Alvarez, Alexandria; Gupta, Rishi; Sun, Chun Huan J; Martin, Coleman; Holloway, William E.; Mueller-Kronast, Nils; English, Joey D.; Malisch, Tim W.; Bozorgchami, Hormozd; Xavier, Andrew; Rai, Ansaar T.; Froehler, Michael T.; Badruddin, Aamir; Nguyen, Thanh N.; Taqi, M. Asif; Abraham, Michael G.; Janardhan, Vallabh; Shaltoni, Hashem; Novakovic, Roberta; Chen, Peng R.; Kaushal, Ritesh; Nanda, Ashish; Issa, Mohammad A.; Nogueira, Raul G.; Zaidat, Osama O.

In: Stroke; a journal of cerebral circulation, Vol. 46, No. 8, 01.08.2015, p. 2305-2308.

Research output: Contribution to journal › Article

Linfante, I, Walker, GR, Castonguay, AC, Dabus, G, Starosciak, AK, Yoo, AJ, Abou-Chebl, A, Britz, GW, Marden, FA, Alvarez, A, Gupta, R, Sun, CHJ, Martin, C, Holloway, WE, Mueller-Kronast, N, English, JD, Malisch, TW, Bozorgchami, H, Xavier, A, Rai, AT, Froehler, MT, Badruddin, A, Nguyen, TN, Taqi, MA, Abraham, MG, Janardhan, V, Shaltoni, H, Novakovic, R, Chen, PR, Kaushal, R, Nanda, A, Issa, MA, Nogueira, RG & Zaidat, OO 2015, 'Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry', Stroke; a journal of cerebral circulation, vol. 46, no. 8, pp. 2305-2308. https://doi.org/10.1161/STROKEAHA.115.009530

Linfante, Italo ; Walker, Gail R. ; Castonguay, Alicia C. ; Dabus, Guilherme ; Starosciak, Amy K. ; Yoo, Albert J. ; Abou-Chebl, Alex ; Britz, Gavin W. ; Marden, Franklin A. ; Alvarez, Alexandria ; Gupta, Rishi ; Sun, Chun Huan J ; Martin, Coleman ; Holloway, William E. ; Mueller-Kronast, Nils ; English, Joey D. ; Malisch, Tim W. ; Bozorgchami, Hormozd ; Xavier, Andrew ; Rai, Ansaar T. ; Froehler, Michael T. ; Badruddin, Aamir ; Nguyen, Thanh N. ; Taqi, M. Asif ; Abraham, Michael G. ; Janardhan, Vallabh ; Shaltoni, Hashem ; Novakovic, Roberta ; Chen, Peng R. ; Kaushal, Ritesh ; Nanda, Ashish ; Issa, Mohammad A. ; Nogueira, Raul G. ; Zaidat, Osama O. / Predictors of Mortality in Acute Ischemic Stroke Intervention : Analysis of the North American Solitaire Acute Stroke Registry. In: Stroke; a journal of cerebral circulation. 2015 ; Vol. 46, No. 8. pp. 2305-2308.

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title = "Predictors of Mortality in Acute Ischemic Stroke Intervention: Analysis of the North American Solitaire Acute Stroke Registry",

abstract = "BACKGROUND AND PURPOSE: Failure to recanalize predicts mortality in acute ischemic stroke. In the North American Solitaire Acute Stroke registry, we investigated parameters associated with mortality in successfully recanalized patients.METHODS: Logistic regression was used to evaluate baseline characteristics and recanalization parameters for association with 90-day mortality. A multivariable model was developed based on backward selection with retention criteria of PRESULTS: Successfully recanalized patients had lower mortality (25.2% [59/234] versus 46.9% [38/81] PCONCLUSIONS: Failure to recanalize and presence of symptomatic intracranial hemorrhage resulted in increased mortality. Despite successful recanalization, proximal occlusion, high National Institutes of Health Stroke Scale, and need for rescue therapy were predictors of mortality.",

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T2 - Analysis of the North American Solitaire Acute Stroke Registry

AU - Linfante, Italo

AU - Walker, Gail R.

AU - Castonguay, Alicia C.

AU - Dabus, Guilherme

AU - Starosciak, Amy K.

AU - Yoo, Albert J.

AU - Abou-Chebl, Alex

AU - Britz, Gavin W.

AU - Marden, Franklin A.

AU - Alvarez, Alexandria

AU - Gupta, Rishi

AU - Sun, Chun Huan J

AU - Martin, Coleman

AU - Holloway, William E.

AU - Mueller-Kronast, Nils

AU - English, Joey D.

AU - Malisch, Tim W.

AU - Bozorgchami, Hormozd

AU - Xavier, Andrew

AU - Rai, Ansaar T.

AU - Froehler, Michael T.

AU - Badruddin, Aamir

AU - Nguyen, Thanh N.

AU - Taqi, M. Asif

AU - Abraham, Michael G.

AU - Janardhan, Vallabh

AU - Shaltoni, Hashem

AU - Novakovic, Roberta

AU - Chen, Peng R.

AU - Kaushal, Ritesh

AU - Nanda, Ashish

AU - Issa, Mohammad A.

AU - Nogueira, Raul G.

AU - Zaidat, Osama O.

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N2 - BACKGROUND AND PURPOSE: Failure to recanalize predicts mortality in acute ischemic stroke. In the North American Solitaire Acute Stroke registry, we investigated parameters associated with mortality in successfully recanalized patients.METHODS: Logistic regression was used to evaluate baseline characteristics and recanalization parameters for association with 90-day mortality. A multivariable model was developed based on backward selection with retention criteria of PRESULTS: Successfully recanalized patients had lower mortality (25.2% [59/234] versus 46.9% [38/81] PCONCLUSIONS: Failure to recanalize and presence of symptomatic intracranial hemorrhage resulted in increased mortality. Despite successful recanalization, proximal occlusion, high National Institutes of Health Stroke Scale, and need for rescue therapy were predictors of mortality.

AB - BACKGROUND AND PURPOSE: Failure to recanalize predicts mortality in acute ischemic stroke. In the North American Solitaire Acute Stroke registry, we investigated parameters associated with mortality in successfully recanalized patients.METHODS: Logistic regression was used to evaluate baseline characteristics and recanalization parameters for association with 90-day mortality. A multivariable model was developed based on backward selection with retention criteria of PRESULTS: Successfully recanalized patients had lower mortality (25.2% [59/234] versus 46.9% [38/81] PCONCLUSIONS: Failure to recanalize and presence of symptomatic intracranial hemorrhage resulted in increased mortality. Despite successful recanalization, proximal occlusion, high National Institutes of Health Stroke Scale, and need for rescue therapy were predictors of mortality.

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KW - intracra

KW - mortality

KW - nial hemorrhages

KW - stroke

KW - thrombectomy

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