Predictors of plaque rupture within nonculprit fibroatheromas in patients with acute coronary syndromes the PROSPECT Study

Bo Zheng, Gary S. Mintz, John A. McPherson, Bernard De Bruyne, Naim Z. Farhat, Steven P. Marso, Patrick W. Serruys, Gregg W. Stone, Akiko Maehara

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives The study sought to examine the relative importance of lesion location versus vessel area and plaque burden in predicting plaque rupture within nonculprit fibroatheromas (FAs) in patients with acute coronary syndromes. Background Previous studies have demonstrated that plaque rupture is associated with larger vessel area and greater plaque burden clustering in the proximal segments of coronary arteries. Methods In the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study 3-vessel grayscale and radiofrequency-intravascular ultrasound was performed after successful percutaneous coronary intervention in 697 patients with acute coronary syndromes. Untreated nonculprit lesion FAs were classified as proximal (40 mm) according to the distance from the ostium to the maximum necrotic core site. Results Overall, 74 ruptured FAs and 2,396 nonruptured FAs were identified in nonculprit vessels. The majority of FAs (73.6%) were located within 40 mm of the ostium, and the vessel area and plaque burden progressively decreased from proximal to distal FA location (both p <0.001). In a multivariate logistic regression model, independent predictors for plaque rupture included the distance from the ostium to the maximum necrotic core site per millimeter (odds ratio [OR]: 0.86; 95% confidence interval [CI]: 0.76 to 0.98; p = 0.02), plaque burden per 10% (OR: 2.05; 95% CI: 1.63 to 2.58; p <0.0001), vessel area per mm2 (OR: 1.14; 95% CI: 1.11 to 1.17; p <0.0001), calcium (OR: 0.09; 95% CI: 0.05 to 0.18; p <0.0001), and right coronary artery location (OR: 2.16; 95% CI: 1.25 to 3.27; p = 0.006). By receiver-operating characteristic analysis, vessel area correlated with plaque rupture stronger than either plaque burden (p <0.001) or location (p <0.001). Conclusions Large vessel area, plaque burden, proximal location, right coronary artery location, and lack of calcium were associated with FA plaque rupture. The present study suggests that among these variables, vessel area may be the strongest predictor of plaque rupture among non-left main coronary arteries. (PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions [PROSPECT]; NCT00180466)

Original languageEnglish (US)
Pages (from-to)1180-1187
Number of pages8
JournalJACC: Cardiovascular Imaging
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2015

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Acute Coronary Syndrome
Rupture
Odds Ratio
Confidence Intervals
Coronary Vessels
Logistic Models
Calcium
Percutaneous Coronary Intervention
ROC Curve
Cluster Analysis

Keywords

  • fibroatheroma
  • intravascular ultrasound
  • plaque rupture

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Predictors of plaque rupture within nonculprit fibroatheromas in patients with acute coronary syndromes the PROSPECT Study. / Zheng, Bo; Mintz, Gary S.; McPherson, John A.; De Bruyne, Bernard; Farhat, Naim Z.; Marso, Steven P.; Serruys, Patrick W.; Stone, Gregg W.; Maehara, Akiko.

In: JACC: Cardiovascular Imaging, Vol. 8, No. 10, 01.10.2015, p. 1180-1187.

Research output: Contribution to journalArticle

Zheng, B, Mintz, GS, McPherson, JA, De Bruyne, B, Farhat, NZ, Marso, SP, Serruys, PW, Stone, GW & Maehara, A 2015, 'Predictors of plaque rupture within nonculprit fibroatheromas in patients with acute coronary syndromes the PROSPECT Study', JACC: Cardiovascular Imaging, vol. 8, no. 10, pp. 1180-1187. https://doi.org/10.1016/j.jcmg.2015.06.014
Zheng, Bo ; Mintz, Gary S. ; McPherson, John A. ; De Bruyne, Bernard ; Farhat, Naim Z. ; Marso, Steven P. ; Serruys, Patrick W. ; Stone, Gregg W. ; Maehara, Akiko. / Predictors of plaque rupture within nonculprit fibroatheromas in patients with acute coronary syndromes the PROSPECT Study. In: JACC: Cardiovascular Imaging. 2015 ; Vol. 8, No. 10. pp. 1180-1187.
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abstract = "Objectives The study sought to examine the relative importance of lesion location versus vessel area and plaque burden in predicting plaque rupture within nonculprit fibroatheromas (FAs) in patients with acute coronary syndromes. Background Previous studies have demonstrated that plaque rupture is associated with larger vessel area and greater plaque burden clustering in the proximal segments of coronary arteries. Methods In the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study 3-vessel grayscale and radiofrequency-intravascular ultrasound was performed after successful percutaneous coronary intervention in 697 patients with acute coronary syndromes. Untreated nonculprit lesion FAs were classified as proximal (40 mm) according to the distance from the ostium to the maximum necrotic core site. Results Overall, 74 ruptured FAs and 2,396 nonruptured FAs were identified in nonculprit vessels. The majority of FAs (73.6{\%}) were located within 40 mm of the ostium, and the vessel area and plaque burden progressively decreased from proximal to distal FA location (both p <0.001). In a multivariate logistic regression model, independent predictors for plaque rupture included the distance from the ostium to the maximum necrotic core site per millimeter (odds ratio [OR]: 0.86; 95{\%} confidence interval [CI]: 0.76 to 0.98; p = 0.02), plaque burden per 10{\%} (OR: 2.05; 95{\%} CI: 1.63 to 2.58; p <0.0001), vessel area per mm2 (OR: 1.14; 95{\%} CI: 1.11 to 1.17; p <0.0001), calcium (OR: 0.09; 95{\%} CI: 0.05 to 0.18; p <0.0001), and right coronary artery location (OR: 2.16; 95{\%} CI: 1.25 to 3.27; p = 0.006). By receiver-operating characteristic analysis, vessel area correlated with plaque rupture stronger than either plaque burden (p <0.001) or location (p <0.001). Conclusions Large vessel area, plaque burden, proximal location, right coronary artery location, and lack of calcium were associated with FA plaque rupture. The present study suggests that among these variables, vessel area may be the strongest predictor of plaque rupture among non-left main coronary arteries. (PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions [PROSPECT]; NCT00180466)",
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author = "Bo Zheng and Mintz, {Gary S.} and McPherson, {John A.} and {De Bruyne}, Bernard and Farhat, {Naim Z.} and Marso, {Steven P.} and Serruys, {Patrick W.} and Stone, {Gregg W.} and Akiko Maehara",
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T1 - Predictors of plaque rupture within nonculprit fibroatheromas in patients with acute coronary syndromes the PROSPECT Study

AU - Zheng, Bo

AU - Mintz, Gary S.

AU - McPherson, John A.

AU - De Bruyne, Bernard

AU - Farhat, Naim Z.

AU - Marso, Steven P.

AU - Serruys, Patrick W.

AU - Stone, Gregg W.

AU - Maehara, Akiko

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objectives The study sought to examine the relative importance of lesion location versus vessel area and plaque burden in predicting plaque rupture within nonculprit fibroatheromas (FAs) in patients with acute coronary syndromes. Background Previous studies have demonstrated that plaque rupture is associated with larger vessel area and greater plaque burden clustering in the proximal segments of coronary arteries. Methods In the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study 3-vessel grayscale and radiofrequency-intravascular ultrasound was performed after successful percutaneous coronary intervention in 697 patients with acute coronary syndromes. Untreated nonculprit lesion FAs were classified as proximal (40 mm) according to the distance from the ostium to the maximum necrotic core site. Results Overall, 74 ruptured FAs and 2,396 nonruptured FAs were identified in nonculprit vessels. The majority of FAs (73.6%) were located within 40 mm of the ostium, and the vessel area and plaque burden progressively decreased from proximal to distal FA location (both p <0.001). In a multivariate logistic regression model, independent predictors for plaque rupture included the distance from the ostium to the maximum necrotic core site per millimeter (odds ratio [OR]: 0.86; 95% confidence interval [CI]: 0.76 to 0.98; p = 0.02), plaque burden per 10% (OR: 2.05; 95% CI: 1.63 to 2.58; p <0.0001), vessel area per mm2 (OR: 1.14; 95% CI: 1.11 to 1.17; p <0.0001), calcium (OR: 0.09; 95% CI: 0.05 to 0.18; p <0.0001), and right coronary artery location (OR: 2.16; 95% CI: 1.25 to 3.27; p = 0.006). By receiver-operating characteristic analysis, vessel area correlated with plaque rupture stronger than either plaque burden (p <0.001) or location (p <0.001). Conclusions Large vessel area, plaque burden, proximal location, right coronary artery location, and lack of calcium were associated with FA plaque rupture. The present study suggests that among these variables, vessel area may be the strongest predictor of plaque rupture among non-left main coronary arteries. (PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions [PROSPECT]; NCT00180466)

AB - Objectives The study sought to examine the relative importance of lesion location versus vessel area and plaque burden in predicting plaque rupture within nonculprit fibroatheromas (FAs) in patients with acute coronary syndromes. Background Previous studies have demonstrated that plaque rupture is associated with larger vessel area and greater plaque burden clustering in the proximal segments of coronary arteries. Methods In the PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) study 3-vessel grayscale and radiofrequency-intravascular ultrasound was performed after successful percutaneous coronary intervention in 697 patients with acute coronary syndromes. Untreated nonculprit lesion FAs were classified as proximal (40 mm) according to the distance from the ostium to the maximum necrotic core site. Results Overall, 74 ruptured FAs and 2,396 nonruptured FAs were identified in nonculprit vessels. The majority of FAs (73.6%) were located within 40 mm of the ostium, and the vessel area and plaque burden progressively decreased from proximal to distal FA location (both p <0.001). In a multivariate logistic regression model, independent predictors for plaque rupture included the distance from the ostium to the maximum necrotic core site per millimeter (odds ratio [OR]: 0.86; 95% confidence interval [CI]: 0.76 to 0.98; p = 0.02), plaque burden per 10% (OR: 2.05; 95% CI: 1.63 to 2.58; p <0.0001), vessel area per mm2 (OR: 1.14; 95% CI: 1.11 to 1.17; p <0.0001), calcium (OR: 0.09; 95% CI: 0.05 to 0.18; p <0.0001), and right coronary artery location (OR: 2.16; 95% CI: 1.25 to 3.27; p = 0.006). By receiver-operating characteristic analysis, vessel area correlated with plaque rupture stronger than either plaque burden (p <0.001) or location (p <0.001). Conclusions Large vessel area, plaque burden, proximal location, right coronary artery location, and lack of calcium were associated with FA plaque rupture. The present study suggests that among these variables, vessel area may be the strongest predictor of plaque rupture among non-left main coronary arteries. (PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions [PROSPECT]; NCT00180466)

KW - fibroatheroma

KW - intravascular ultrasound

KW - plaque rupture

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