Preface: A special issue on nuclear receptors with a special view on the molecular basis of disease

TY - JOUR

T1 - Preface

T2 - A special issue on nuclear receptors with a special view on the molecular basis of disease

AU - Moschetta, Antonio

N1 - Funding Information: Antonio Moschetta is a physician scientist. He is the head of the laboratory of lipid metabolism and cancer at the Consorzio Mario Negri Sud and he works as internist at the Clinica Medica “Murri” at the University of Bari in Italy. He had been trained in Italy as Medical Doctor at the University of Bari; he took his PhD in The Netherlands at the University of Utrecht Medical Center and he did his postdoctoral studies at The Howard Hughes Medical Institute at The University of Texas Southwestern Medical Center, Dallas, USA. Moschetta laboratory's main interest focuses on the basic processes that regulate lipid metabolism in the gastro-intestinal and hepato-biliary tract. The group aims at investigating how nuclear receptors could transcriptionally link the metabolism of glucose and lipids with the initiation and/or progression of the cancer progress in the intestinal epithelium. His specific strategy is to identify the interconnection of transcriptional and metabolic pathways in the gut–liver axis with relevance to systemic disease such as metabolic syndrome and cancer. His latest focus is on how nutrients could activate and/or inhibit nuclear receptor transcriptional activity, thus linking diet to DNA. His group is looking for designing novel gene expression maps that could predict the relationship between nutrients and evolution of cancer. The final hope is that clustering the genes that depict the invasive picture of certain tumors or the increased cardiovascular risks of specific subjects would lead to a better molecular understanding of the pathogenesis and in the future more effective ad personam therapeutic approaches. The recent work of Antonio Moschetta is supported by the Italian Association for Cancer Research, Telethon Foundation, European Community's Seventh Framework Programme, Italian Ministry of Health (Young Investigator award), Italian Ministry of Research and Education (IDEAS award), University of Bari, Italy.

PY - 2011/8

Y1 - 2011/8

UR - http://www.scopus.com/inward/record.url?scp=79958269770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958269770&partnerID=8YFLogxK

U2 - 10.1016/j.bbadis.2011.05.009

DO - 10.1016/j.bbadis.2011.05.009

M3 - Editorial

C2 - 21664556

AN - SCOPUS:79958269770

SN - 0925-4439

VL - 1812

SP - 807

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

IS - 8

ER -