Prefrontal cortex fMRI signal changes are correlated with working memory load

Dara S. Manoach; Gottfried Schlaug; Bettina Siewert; David G. Darby; Benjamin Martin Bly; Andrew Benfield; Robert R. Edelman; Steven Warach

doi:10.1097/00001756-199701200-00033

Prefrontal cortex fMRI signal changes are correlated with working memory load

Dara S. Manoach, Gottfried Schlaug, Bettina Siewert, David G. Darby, Benjamin Martin Bly, Andrew Benfield, Robert R. Edelman, Steven Warach

Neurology & Neurotherapeutics

Research output: Contribution to journal › Article › peer-review

222 Scopus citations

Abstract

We investigated whether a nonspatial working memory (WM) task would activate dorsolateral prefrontal cortex (DLPFC) and whether activation would be correlated with WM load. Using functional magnetic resonance imaging we measured regional brain signal changes in 12 normal subjects performing a continuous performance, choice reaction time task that requires WM. A high WM load condition was compared with a non-WM choice reaction time control condition (WM effect) and a low WM load condition (load effect). Significant changes in signal intensity occurred in the DLPFC, frontal motor regions and the intraparietal sulcus (IPS) in both comparisons. These findings support the role of DLPFC and IPS in WM and suggest that signal changes in DLPFC correlate with WM load.

Original language	English (US)
Pages (from-to)	545-549
Number of pages	5
Journal	NeuroReport
Volume	8
Issue number	2
DOIs	https://doi.org/10.1097/00001756-199701200-00033
State	Published - Jan 1 1997

Keywords

Functional MRI
Intraparietal sulcus
Prefrontal cortex
Working memory

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199701200-00033

Cite this

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title = "Prefrontal cortex fMRI signal changes are correlated with working memory load",

abstract = "We investigated whether a nonspatial working memory (WM) task would activate dorsolateral prefrontal cortex (DLPFC) and whether activation would be correlated with WM load. Using functional magnetic resonance imaging we measured regional brain signal changes in 12 normal subjects performing a continuous performance, choice reaction time task that requires WM. A high WM load condition was compared with a non-WM choice reaction time control condition (WM effect) and a low WM load condition (load effect). Significant changes in signal intensity occurred in the DLPFC, frontal motor regions and the intraparietal sulcus (IPS) in both comparisons. These findings support the role of DLPFC and IPS in WM and suggest that signal changes in DLPFC correlate with WM load.",

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AU - Manoach, Dara S.

AU - Schlaug, Gottfried

AU - Siewert, Bettina

AU - Darby, David G.

AU - Bly, Benjamin Martin

AU - Benfield, Andrew

AU - Edelman, Robert R.

AU - Warach, Steven

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Prefrontal cortex fMRI signal changes are correlated with working memory load

Abstract

Keywords

ASJC Scopus subject areas

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