Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome

Madeline Murguia Rice, Mark B. Landon, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, Joseph R. Biggio, John M. Thorp, Edward K. Chien, George Saade, Alan M. Peaceman, Sean C. Blackwell, J. Peter Vandorsten

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47% of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29%) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95% confidence interval [CI] 1.95-4.80, P

Original languageEnglish (US)
Pages (from-to)771-779
Number of pages9
JournalObstetrics and Gynecology
Volume127
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Hypertension
Glucose
Pregnancy
Glucose Intolerance
Observational Studies
Pregnancy Induced Hypertension
Gestational Diabetes
Pre-Eclampsia
Fasting
Cohort Studies
Mothers
Confidence Intervals
Blood Pressure
Lipids
Serum
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Rice, M. M., Landon, M. B., Varner, M. W., Casey, B. M., Reddy, U. M., Wapner, R. J., ... Vandorsten, J. P. (2016). Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome. Obstetrics and Gynecology, 127(4), 771-779. https://doi.org/10.1097/AOG.0000000000001353

Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome. / Rice, Madeline Murguia; Landon, Mark B.; Varner, Michael W.; Casey, Brian M.; Reddy, Uma M.; Wapner, Ronald J.; Rouse, Dwight J.; Biggio, Joseph R.; Thorp, John M.; Chien, Edward K.; Saade, George; Peaceman, Alan M.; Blackwell, Sean C.; Vandorsten, J. Peter.

In: Obstetrics and Gynecology, Vol. 127, No. 4, 01.04.2016, p. 771-779.

Research output: Contribution to journalArticle

Rice, MM, Landon, MB, Varner, MW, Casey, BM, Reddy, UM, Wapner, RJ, Rouse, DJ, Biggio, JR, Thorp, JM, Chien, EK, Saade, G, Peaceman, AM, Blackwell, SC & Vandorsten, JP 2016, 'Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome', Obstetrics and Gynecology, vol. 127, no. 4, pp. 771-779. https://doi.org/10.1097/AOG.0000000000001353
Rice, Madeline Murguia ; Landon, Mark B. ; Varner, Michael W. ; Casey, Brian M. ; Reddy, Uma M. ; Wapner, Ronald J. ; Rouse, Dwight J. ; Biggio, Joseph R. ; Thorp, John M. ; Chien, Edward K. ; Saade, George ; Peaceman, Alan M. ; Blackwell, Sean C. ; Vandorsten, J. Peter. / Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome. In: Obstetrics and Gynecology. 2016 ; Vol. 127, No. 4. pp. 771-779.
@article{0b26c21715a2456ebb239dc4612fcd14,
title = "Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome",
abstract = "OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47{\%} of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29{\%}) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95{\%} confidence interval [CI] 1.95-4.80, P",
author = "Rice, {Madeline Murguia} and Landon, {Mark B.} and Varner, {Michael W.} and Casey, {Brian M.} and Reddy, {Uma M.} and Wapner, {Ronald J.} and Rouse, {Dwight J.} and Biggio, {Joseph R.} and Thorp, {John M.} and Chien, {Edward K.} and George Saade and Peaceman, {Alan M.} and Blackwell, {Sean C.} and Vandorsten, {J. Peter}",
year = "2016",
month = "4",
day = "1",
doi = "10.1097/AOG.0000000000001353",
language = "English (US)",
volume = "127",
pages = "771--779",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Pregnancy-associated hypertension in glucose-intolerant pregnancy and subsequent metabolic syndrome

AU - Rice, Madeline Murguia

AU - Landon, Mark B.

AU - Varner, Michael W.

AU - Casey, Brian M.

AU - Reddy, Uma M.

AU - Wapner, Ronald J.

AU - Rouse, Dwight J.

AU - Biggio, Joseph R.

AU - Thorp, John M.

AU - Chien, Edward K.

AU - Saade, George

AU - Peaceman, Alan M.

AU - Blackwell, Sean C.

AU - Vandorsten, J. Peter

PY - 2016/4/1

Y1 - 2016/4/1

N2 - OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47% of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29%) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95% confidence interval [CI] 1.95-4.80, P

AB - OBJECTIVE: To evaluate whether pregnancy-associated hypertension (preeclampsia or gestational hypertension) among women with varying degrees of glucose intolerance during pregnancy is associated with maternal metabolic syndrome 5-10 years later. METHODS: This was an observational cohort study of women previously enrolled in a treatment trial of mild gestational diabetes mellitus or an observational study of lesser degrees of glucose intolerance evaluated 5-10 years after their index pregnancy. At follow-up, women underwent anthropometric and blood pressure measurements and analysis of fasting glucose and serum lipids. RESULTS: A total of 825 women (47% of eligible women from the original study) were included in this analysis and evaluated at a median 7 years after their index pregnancy at a median age of 35 years. Overall, 239 (29%) had subsequent metabolic syndrome. The frequency of metabolic syndrome and its components was highest in the women who had pregnancy-associated hypertension and delivered preterm. After adjusting for confounding factors, pregnancy-associated hypertension in women who delivered preterm was associated with subsequent hypertension (130/85 mm Hg or greater; relative risk 3.06, 95% confidence interval [CI] 1.95-4.80, P

UR - http://www.scopus.com/inward/record.url?scp=84960158165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960158165&partnerID=8YFLogxK

U2 - 10.1097/AOG.0000000000001353

DO - 10.1097/AOG.0000000000001353

M3 - Article

C2 - 26959208

AN - SCOPUS:84960158165

VL - 127

SP - 771

EP - 779

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 4

ER -