Abstract
Background. Traumatic brain injury (TBI) often leads to mood and cognitive complications, affecting functional recovery. Understanding neurobiological alterations common in post-TBI depression (PTD) and cognition may identify novel biomarkers for TBI complications. Brain-derived neurotrophic factor (BDNF) is a likely target based on evidence of reduced BDNF signaling in experimental TBI and depression models and its role in learning and memory. Objective. To evaluate BDNF as a biomarker for PTD, cognitive impairment, and functional cognition in a prospective cohort with severe TBI. Methods. Participants with TBI (n = 113) were evaluated for PTD (Patient Health Questionnaire-9 [PHQ-9]), cognitive impairment (cognitive composite score), and functional cognition (Functional Independence Measure-Cognition, FIM-Cog). BDNF levels were measured in cerebrospinal fluid and serum at 0 to 6 days postinjury and in serum at 6 and 12 months postinjury. Results. Serum BDNF was reduced after TBI versus controls at all time points. Acute serum BDNF positively correlated with memory composites (6 months: r = 0.43, P =.019, n = 30; 12 months: r = 0.53, P =.005, n = 26) and FIM-Memory scores (6 months: r = 0.35, P =.019, n = 45; 12 months: r = 0.38, P =.018, n = 38). Acute serum BDNF negatively correlated with 12-month PHQ-9 scores (r = '0.38; P =.044; n = 29). At 12 months, chronic serum BDNF tended to be lower in participants with PTD (P =.07) and correlated with PHQ-9 scores (r = '0.41; P =.019; n = 32). Conclusions. Acute BDNF associations with memory recovery may implicate hippocampal damage/degeneration. Comparatively, BDNF associations with PTD status were not as strong as associations with PTD severity. Further investigation may delineate longitudinal BDNF patterns, and BDNF responsive treatments, reflecting mood and cognitive recovery following TBI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 419-430 |
| Number of pages | 12 |
| Journal | Neurorehabilitation and Neural Repair |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2015 |
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Keywords
- BDNF
- biomarker
- cognitive impairment
- depression
- rehabilomics
- traumatic brain injury
ASJC Scopus subject areas
- Rehabilitation
- Neurology
- Clinical Neurology
Cite this
Preliminary Associations between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI. / Failla, Michelle D.; Juengst, Shannon B.; Arenth, Patricia M.; Wagner, Amy K.
In: Neurorehabilitation and Neural Repair, Vol. 30, No. 5, 01.01.2015, p. 419-430.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preliminary Associations between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI
AU - Failla, Michelle D.
AU - Juengst, Shannon B.
AU - Arenth, Patricia M.
AU - Wagner, Amy K.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background. Traumatic brain injury (TBI) often leads to mood and cognitive complications, affecting functional recovery. Understanding neurobiological alterations common in post-TBI depression (PTD) and cognition may identify novel biomarkers for TBI complications. Brain-derived neurotrophic factor (BDNF) is a likely target based on evidence of reduced BDNF signaling in experimental TBI and depression models and its role in learning and memory. Objective. To evaluate BDNF as a biomarker for PTD, cognitive impairment, and functional cognition in a prospective cohort with severe TBI. Methods. Participants with TBI (n = 113) were evaluated for PTD (Patient Health Questionnaire-9 [PHQ-9]), cognitive impairment (cognitive composite score), and functional cognition (Functional Independence Measure-Cognition, FIM-Cog). BDNF levels were measured in cerebrospinal fluid and serum at 0 to 6 days postinjury and in serum at 6 and 12 months postinjury. Results. Serum BDNF was reduced after TBI versus controls at all time points. Acute serum BDNF positively correlated with memory composites (6 months: r = 0.43, P =.019, n = 30; 12 months: r = 0.53, P =.005, n = 26) and FIM-Memory scores (6 months: r = 0.35, P =.019, n = 45; 12 months: r = 0.38, P =.018, n = 38). Acute serum BDNF negatively correlated with 12-month PHQ-9 scores (r = '0.38; P =.044; n = 29). At 12 months, chronic serum BDNF tended to be lower in participants with PTD (P =.07) and correlated with PHQ-9 scores (r = '0.41; P =.019; n = 32). Conclusions. Acute BDNF associations with memory recovery may implicate hippocampal damage/degeneration. Comparatively, BDNF associations with PTD status were not as strong as associations with PTD severity. Further investigation may delineate longitudinal BDNF patterns, and BDNF responsive treatments, reflecting mood and cognitive recovery following TBI.
AB - Background. Traumatic brain injury (TBI) often leads to mood and cognitive complications, affecting functional recovery. Understanding neurobiological alterations common in post-TBI depression (PTD) and cognition may identify novel biomarkers for TBI complications. Brain-derived neurotrophic factor (BDNF) is a likely target based on evidence of reduced BDNF signaling in experimental TBI and depression models and its role in learning and memory. Objective. To evaluate BDNF as a biomarker for PTD, cognitive impairment, and functional cognition in a prospective cohort with severe TBI. Methods. Participants with TBI (n = 113) were evaluated for PTD (Patient Health Questionnaire-9 [PHQ-9]), cognitive impairment (cognitive composite score), and functional cognition (Functional Independence Measure-Cognition, FIM-Cog). BDNF levels were measured in cerebrospinal fluid and serum at 0 to 6 days postinjury and in serum at 6 and 12 months postinjury. Results. Serum BDNF was reduced after TBI versus controls at all time points. Acute serum BDNF positively correlated with memory composites (6 months: r = 0.43, P =.019, n = 30; 12 months: r = 0.53, P =.005, n = 26) and FIM-Memory scores (6 months: r = 0.35, P =.019, n = 45; 12 months: r = 0.38, P =.018, n = 38). Acute serum BDNF negatively correlated with 12-month PHQ-9 scores (r = '0.38; P =.044; n = 29). At 12 months, chronic serum BDNF tended to be lower in participants with PTD (P =.07) and correlated with PHQ-9 scores (r = '0.41; P =.019; n = 32). Conclusions. Acute BDNF associations with memory recovery may implicate hippocampal damage/degeneration. Comparatively, BDNF associations with PTD status were not as strong as associations with PTD severity. Further investigation may delineate longitudinal BDNF patterns, and BDNF responsive treatments, reflecting mood and cognitive recovery following TBI.
KW - BDNF
KW - biomarker
KW - cognitive impairment
KW - depression
KW - rehabilomics
KW - traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84965079511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965079511&partnerID=8YFLogxK
U2 - 10.1177/1545968315600525
DO - 10.1177/1545968315600525
M3 - Article
C2 - 26276123
AN - SCOPUS:84965079511
VL - 30
SP - 419
EP - 430
JO - Journal of Neurologic Rehabilitation
JF - Journal of Neurologic Rehabilitation
SN - 0888-4390
IS - 5
ER -