TY - JOUR
T1 - Premorbid indicators and risk for schizophrenia
T2 - A selective review and update
AU - Keshavan, Matcheri S.
AU - Diwadkar, Vaibhav A.
AU - Montrose, Debra M.
AU - Rajarethinam, Rajaprabhakaran
AU - Sweeney, John A.
N1 - Funding Information:
This work was supported in part by NIMH grants MH 64023, 01180 (MSK), 68680 (VAD), 62134, 01433 and a NARSAD independent Investigator award (MSK), NARSAD Young Investigator awards (DMM, VAD) and GCRC grant M01 RR00056. We thank Diana Dworakowski MS for help supervising the recruitment and clinical assessments and Jeffrey Nutche BS and Madhuri Vemulapalli MS for image processing.
PY - 2005/11/1
Y1 - 2005/11/1
N2 - Prospective studies of young relatives at risk for schizophrenia (high-risk studies, HR) can shed light on premorbid precursors of schizophrenia. Early HR studies pointed to a wide prevalence of schizophrenia spectrum psychopathology among young relatives at increased genetic risk. Recent studies suggest that young HR relatives have neurobehavioral deficits and structural, physiological, and neurochemical brain abnormalities that may date back to childhood or earlier. In this paper, we provide a selected overview of the lessons and limitations of early "first generation" studies and the beginning insights from recent "second generation" studies. We also provide an interim summary of data from the ongoing studies of young relatives at risk for schizophrenia in Pittsburgh. Collectively, such data may help us to predict the eventual emergence of schizophrenia, and schizophrenia spectrum or non-spectrum psychopathology.
AB - Prospective studies of young relatives at risk for schizophrenia (high-risk studies, HR) can shed light on premorbid precursors of schizophrenia. Early HR studies pointed to a wide prevalence of schizophrenia spectrum psychopathology among young relatives at increased genetic risk. Recent studies suggest that young HR relatives have neurobehavioral deficits and structural, physiological, and neurochemical brain abnormalities that may date back to childhood or earlier. In this paper, we provide a selected overview of the lessons and limitations of early "first generation" studies and the beginning insights from recent "second generation" studies. We also provide an interim summary of data from the ongoing studies of young relatives at risk for schizophrenia in Pittsburgh. Collectively, such data may help us to predict the eventual emergence of schizophrenia, and schizophrenia spectrum or non-spectrum psychopathology.
KW - High-risk
KW - Imaging
KW - Schizophrenia
KW - Schizotypy
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U2 - 10.1016/j.schres.2005.07.004
DO - 10.1016/j.schres.2005.07.004
M3 - Article
C2 - 16139479
AN - SCOPUS:25444478921
SN - 0920-9964
VL - 79
SP - 45
EP - 57
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -