Preoperative Continuation Versus Interruption of Oral Hypoglycemics in Type 2 Diabetic Patients Undergoing Ambulatory Surgery: A Randomized Controlled Trial

Irina Gasanova, Jin Meng, Abu Minhajuddin, Emily Melikman, John C. Alexander, Girish P. Joshi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients with type 2 diabetes mellitus receiving oral hypoglycemic drugs (OHDs) are usually instructed to stop them before surgery. We hypothesize that continuing OHD preoperatively should result in lower perioperative blood glucose (BG) levels. Ambulatory surgery patients with type 2 diabetes mellitus on OHDs were randomized to continue (n = 69) or withhold (n = 73) OHDs preoperatively. Log-transformed BG levels at pre-, intra-, and postoperative periods were analyzed. Perioperative BG levels were significantly lower (mean, 138 mg/dL; 95% confidence interval, 130-146 mg/dL) in the group that continued versus the group that discontinued OHDs (mean, 156 mg/dL; 95% confidence interval, 146-167 mg/dL; P < .001).

Original languageEnglish (US)
Pages (from-to)e54-e56
JournalAnesthesia and analgesia
Volume127
Issue number4
DOIs
StatePublished - Oct 1 2018

Fingerprint

Ambulatory Surgical Procedures
Hypoglycemic Agents
Randomized Controlled Trials
Blood Glucose
Type 2 Diabetes Mellitus
Intraoperative Period
Confidence Intervals
Postoperative Period

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

@article{7b1e551e016b47eb9f2bfa861eb9eb0f,
title = "Preoperative Continuation Versus Interruption of Oral Hypoglycemics in Type 2 Diabetic Patients Undergoing Ambulatory Surgery: A Randomized Controlled Trial",
abstract = "Patients with type 2 diabetes mellitus receiving oral hypoglycemic drugs (OHDs) are usually instructed to stop them before surgery. We hypothesize that continuing OHD preoperatively should result in lower perioperative blood glucose (BG) levels. Ambulatory surgery patients with type 2 diabetes mellitus on OHDs were randomized to continue (n = 69) or withhold (n = 73) OHDs preoperatively. Log-transformed BG levels at pre-, intra-, and postoperative periods were analyzed. Perioperative BG levels were significantly lower (mean, 138 mg/dL; 95{\%} confidence interval, 130-146 mg/dL) in the group that continued versus the group that discontinued OHDs (mean, 156 mg/dL; 95{\%} confidence interval, 146-167 mg/dL; P < .001).",
author = "Irina Gasanova and Jin Meng and Abu Minhajuddin and Emily Melikman and Alexander, {John C.} and Joshi, {Girish P.}",
year = "2018",
month = "10",
day = "1",
doi = "10.1213/ANE.0000000000003675",
language = "English (US)",
volume = "127",
pages = "e54--e56",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Preoperative Continuation Versus Interruption of Oral Hypoglycemics in Type 2 Diabetic Patients Undergoing Ambulatory Surgery

T2 - A Randomized Controlled Trial

AU - Gasanova, Irina

AU - Meng, Jin

AU - Minhajuddin, Abu

AU - Melikman, Emily

AU - Alexander, John C.

AU - Joshi, Girish P.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Patients with type 2 diabetes mellitus receiving oral hypoglycemic drugs (OHDs) are usually instructed to stop them before surgery. We hypothesize that continuing OHD preoperatively should result in lower perioperative blood glucose (BG) levels. Ambulatory surgery patients with type 2 diabetes mellitus on OHDs were randomized to continue (n = 69) or withhold (n = 73) OHDs preoperatively. Log-transformed BG levels at pre-, intra-, and postoperative periods were analyzed. Perioperative BG levels were significantly lower (mean, 138 mg/dL; 95% confidence interval, 130-146 mg/dL) in the group that continued versus the group that discontinued OHDs (mean, 156 mg/dL; 95% confidence interval, 146-167 mg/dL; P < .001).

AB - Patients with type 2 diabetes mellitus receiving oral hypoglycemic drugs (OHDs) are usually instructed to stop them before surgery. We hypothesize that continuing OHD preoperatively should result in lower perioperative blood glucose (BG) levels. Ambulatory surgery patients with type 2 diabetes mellitus on OHDs were randomized to continue (n = 69) or withhold (n = 73) OHDs preoperatively. Log-transformed BG levels at pre-, intra-, and postoperative periods were analyzed. Perioperative BG levels were significantly lower (mean, 138 mg/dL; 95% confidence interval, 130-146 mg/dL) in the group that continued versus the group that discontinued OHDs (mean, 156 mg/dL; 95% confidence interval, 146-167 mg/dL; P < .001).

UR - http://www.scopus.com/inward/record.url?scp=85070245607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070245607&partnerID=8YFLogxK

U2 - 10.1213/ANE.0000000000003675

DO - 10.1213/ANE.0000000000003675

M3 - Article

C2 - 30044293

AN - SCOPUS:85070245607

VL - 127

SP - e54-e56

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 4

ER -