Preoperative risk factors for nasal carriage of Staphylococcus aureus

Loreen A. Herwaldt, Joseph J. Cullen, Pamela French, Jianfang Hu, Michael A. Pfaller, Richard P. Wenzel, Trish M. Perl

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

BACKGROUND: Staphylococcus aureus nasal carriage is a risk factor for surgical-site infections (SSIs) caused by S. aureus, and eradication of carriage reduces postoperative nosocomial infections caused by it. No study has compared large groups of preoperative carriers and non-carriers to identify factors that are linked to S. aureus nasal carriage. METHODS. While conducting a clinical trial evaluating whether mupirocin prevented S. aureus SSIs, we prospectively collected data on 70 patient characteristics that might be associated with S. aureus carriage. We performed stepwise logistic regression analysis. RESULTS: Of the 4,030 patients, 891 (22%) carried S. aureus. Independent risk factors for S. aureus nasal carriage were obesity (odds ratio [OR], 1.29; 95% confidence interval [CI 95], 1.11-1.50), male gender (OR, 1.29; CI 95, 1.11-1.51), and a history of a cerebrovascular accident (OR, 1.53; CI 95, 1.03-2.25) for all patients. Factors associated with nasal carriage varied somewhat by surgical specialty. In all groups, preoperative use of antimicrobial agents was independently associated with a lower risk of carrying S. aureus in the nares. Previously identified risk factors were not significantly associated with S. aureus nasal carriage in this large group of surgical patients. CONCLUSION: Male gender, obesity, and a history of a cerebrovascular accident were identified as risk factors for S. aureus nasal carriage. It remains to be seen whether preoperative weight loss would reduce the rate of nasal carriage. In addition, the value of screening this patient population for S. aureus nasal carriage merits further investigation.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalInfection Control and Hospital Epidemiology
Volume25
Issue number6
DOIs
StatePublished - Jun 1 2004

Fingerprint

Nose
Staphylococcus aureus
Surgical Wound Infection
Odds Ratio
Obesity
Stroke
Mupirocin
Surgical Specialties
Cross Infection
Anti-Infective Agents
Weight Loss
Logistic Models
Regression Analysis
Clinical Trials
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Herwaldt, L. A., Cullen, J. J., French, P., Hu, J., Pfaller, M. A., Wenzel, R. P., & Perl, T. M. (2004). Preoperative risk factors for nasal carriage of Staphylococcus aureus. Infection Control and Hospital Epidemiology, 25(6), 481-484. https://doi.org/10.1086/502426

Preoperative risk factors for nasal carriage of Staphylococcus aureus. / Herwaldt, Loreen A.; Cullen, Joseph J.; French, Pamela; Hu, Jianfang; Pfaller, Michael A.; Wenzel, Richard P.; Perl, Trish M.

In: Infection Control and Hospital Epidemiology, Vol. 25, No. 6, 01.06.2004, p. 481-484.

Research output: Contribution to journalArticle

Herwaldt, LA, Cullen, JJ, French, P, Hu, J, Pfaller, MA, Wenzel, RP & Perl, TM 2004, 'Preoperative risk factors for nasal carriage of Staphylococcus aureus', Infection Control and Hospital Epidemiology, vol. 25, no. 6, pp. 481-484. https://doi.org/10.1086/502426
Herwaldt LA, Cullen JJ, French P, Hu J, Pfaller MA, Wenzel RP et al. Preoperative risk factors for nasal carriage of Staphylococcus aureus. Infection Control and Hospital Epidemiology. 2004 Jun 1;25(6):481-484. https://doi.org/10.1086/502426
Herwaldt, Loreen A. ; Cullen, Joseph J. ; French, Pamela ; Hu, Jianfang ; Pfaller, Michael A. ; Wenzel, Richard P. ; Perl, Trish M. / Preoperative risk factors for nasal carriage of Staphylococcus aureus. In: Infection Control and Hospital Epidemiology. 2004 ; Vol. 25, No. 6. pp. 481-484.
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