Preparation of high specific activity glucagon I131

M. S. McCall, D. L. Timm, A. M. Eisentraut, Roger H Unger

Research output: Contribution to journalArticle

Abstract

A simple, rapid, and reliable method for radioiodination of glucagon has been described. By this technique, 12 to 28 per cent of the I131 was incorporated in the protein and specific activities of approximately 200 mc. per milligram were obtained. The entire procedure, which could be completed within 4 hours, usually yielded a product 93 to 99 per cent of which was identified chromatographically as undamaged glucagon I131.

Original languageEnglish (US)
Pages (from-to)351-356
Number of pages6
JournalThe Journal of laboratory and clinical medicine
Volume59
Issue number2
StatePublished - Feb 1 1962

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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