Preparation of neutron-activatable holmium nanoparticles for the treatment of ovarian cancer metastases

Anthony J. Di Pasqua, James E. Huckle, Jin Ki Kim, Younjee Chung, Andrew Z. Wang, Michael Jay, Xiuling Lu

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Nanoparticles containing stable holmium ( 165Ho) are prepared by nanotemplate engineering and subsequently irradiated in a neutron flux to yield 166Ho, a beta-emitting radiotherapeutic isotope. After intraperitoneal injection to mice bearing SKOV-3 ovarian tumors, significant tumor accumulation of the 166Ho-nanoparticles is observed by SPECT imaging indicating the potential of these neutron activatable nanoparticles for internal radiation therapy of ovarian cancer metastases.

Original languageEnglish (US)
Pages (from-to)997-1000
Number of pages4
JournalSmall
Volume8
Issue number7
DOIs
StatePublished - Apr 10 2012
Externally publishedYes

Keywords

  • drug delivery
  • holmium
  • imaging
  • nanoparticle
  • ovarian cancer

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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