Presence of simian virus 40 DNA sequences in human lymphomas

Narayan Shivapurkar; Kenichi Harada; Jyotsna Reddy; Richard H. Scheuermann; Yin Xu; Robert W. McKenna; Sara Milchgrub; Steven H. Kroft; Ziding Feng; Adi F. Gazdar

doi:10.1016/S0140-6736(02)07921-7

Presence of simian virus 40 DNA sequences in human lymphomas

Narayan Shivapurkar, Kenichi Harada, Jyotsna Reddy, Richard H. Scheuermann, Yin Xu, Robert W. McKenna, Sara Milchgrub, Steven H. Kroft, Ziding Feng, Adi F. Gazdar

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

Original language	English (US)
Pages (from-to)	851-852
Number of pages	2
Journal	Lancet
Volume	359
Issue number	9309
DOIs	https://doi.org/10.1016/S0140-6736(02)07921-7
State	Published - Mar 9 2002

ASJC Scopus subject areas

Medicine(all)

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title = "Presence of simian virus 40 DNA sequences in human lymphomas",

abstract = "Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.",

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T1 - Presence of simian virus 40 DNA sequences in human lymphomas

AU - Shivapurkar, Narayan

AU - Harada, Kenichi

AU - Reddy, Jyotsna

AU - Scheuermann, Richard H.

AU - Xu, Yin

AU - McKenna, Robert W.

AU - Milchgrub, Sara

AU - Kroft, Steven H.

AU - Feng, Ziding

AU - Gazdar, Adi F.

PY - 2002/3/9

Y1 - 2002/3/9

N2 - Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

AB - Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

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