TY - JOUR
T1 - Presence of simian virus 40 DNA sequences in human lymphomas
AU - Shivapurkar, Narayan
AU - Harada, Kenichi
AU - Reddy, Jyotsna
AU - Scheuermann, Richard H.
AU - Xu, Yin
AU - McKenna, Robert W.
AU - Milchgrub, Sara
AU - Kroft, Steven H.
AU - Feng, Ziding
AU - Gazdar, Adi F.
PY - 2002/3/9
Y1 - 2002/3/9
N2 - Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.
AB - Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.
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U2 - 10.1016/S0140-6736(02)07921-7
DO - 10.1016/S0140-6736(02)07921-7
M3 - Article
C2 - 11897287
AN - SCOPUS:0037045832
VL - 359
SP - 851
EP - 852
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9309
ER -