Presence of simian virus 40 DNA sequences in human lymphomas

Narayan Shivapurkar, Kenichi Harada, Jyotsna Reddy, Richard H. Scheuermann, Yin Xu, Robert W. McKenna, Sara Milchgrub, Steven H. Kroft, Ziding Feng, Adi F. Gazdar

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136 Scopus citations

Abstract

Simian virus 40 (SV40) - a potent oncogenic virus - has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

Original languageEnglish (US)
Pages (from-to)851-852
Number of pages2
JournalLancet
Volume359
Issue number9309
DOIs
StatePublished - Mar 9 2002

ASJC Scopus subject areas

  • Medicine(all)

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    Shivapurkar, N., Harada, K., Reddy, J., Scheuermann, R. H., Xu, Y., McKenna, R. W., Milchgrub, S., Kroft, S. H., Feng, Z., & Gazdar, A. F. (2002). Presence of simian virus 40 DNA sequences in human lymphomas. Lancet, 359(9309), 851-852. https://doi.org/10.1016/S0140-6736(02)07921-7