TY - JOUR
T1 - Presenilins
T2 - A novel link between intracellular calcium signaling and lysosomal function?
AU - Bezprozvanny, Ilya
PY - 2012/7/9
Y1 - 2012/7/9
N2 - Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer's disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FADassociated PS mutations, which have been previously attributed to a function for PS in lysosomal acidification. Now, in this issue, Coen et al. (2012. J. Cell Biol. http://dx .doi.org/10.1083/jcb.201201076) provide a series of results that challenge this idea and propose instead that presenilins play a role in calcium-mediated lysosomal fusion.
AB - Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer's disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FADassociated PS mutations, which have been previously attributed to a function for PS in lysosomal acidification. Now, in this issue, Coen et al. (2012. J. Cell Biol. http://dx .doi.org/10.1083/jcb.201201076) provide a series of results that challenge this idea and propose instead that presenilins play a role in calcium-mediated lysosomal fusion.
UR - http://www.scopus.com/inward/record.url?scp=84865062472&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865062472&partnerID=8YFLogxK
U2 - 10.1083/jcb.201206003
DO - 10.1083/jcb.201206003
M3 - Article
C2 - 22778275
AN - SCOPUS:84865062472
SN - 0021-9525
VL - 198
SP - 7
EP - 10
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 1
ER -