Presenilins: A novel link between intracellular calcium signaling and lysosomal function?

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Abstract

Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer's disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FADassociated PS mutations, which have been previously attributed to a function for PS in lysosomal acidification. Now, in this issue, Coen et al. (2012. J. Cell Biol. http://dx .doi.org/10.1083/jcb.201201076) provide a series of results that challenge this idea and propose instead that presenilins play a role in calcium-mediated lysosomal fusion.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Cell Biology
Volume198
Issue number1
DOIs
StatePublished - Jul 9 2012

ASJC Scopus subject areas

  • Cell Biology

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