Presenilins interact with armadillo proteins including neural- specific plakophilin-related protein and β-catenin

G. Levesque, G. Yu, M. Nishimura, D. M. Zhang, L. Levesque, H. Yu, D. Xu, Y. Liang, E. Rogaeva, M. Ikeda, M. Duthie, N. Murgolo, L. Wang, P. VanderVere, M. L. Bayne, C. D. Strader, J. M. Rommens, P. E. Fraser, P. St. George-Hyslop

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Missense substitutions in the presenilin 1 (PS1) and presenilin 2 (PS2) proteins are associated with early-onset familial Alzheimer's disease. We have used yeast-two-hybrid and coimmunoprecipitation methods to show that the large cytoplasmic loop domains of PS1 and PS2 interact specifically with three members of the armadillo protein family, including β-catenin, p0071, and a novel neuronal-specific armadillo protein-neural plakophilin-related armadillo protein (NPRAP). The PS1:NPRAP interaction occurs between the arm repeats of NPRAP and residues 372-399 at the C-terminal end of the large cytoplasmic loop of PS1. The latter residues contain a single arm-like domain and are highly conserved in the presenilins, suggesting that they form a functional armadillo protein binding site for the presenilins.

Original languageEnglish (US)
Pages (from-to)999-1008
Number of pages10
JournalJournal of Neurochemistry
Volume72
Issue number3
DOIs
StatePublished - Feb 24 1999

Keywords

  • Alzheimer's disease
  • Armadillo proteins
  • Presenilin binding proteins
  • Presenilin proteins
  • Yeast-two-hybrid

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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    Levesque, G., Yu, G., Nishimura, M., Zhang, D. M., Levesque, L., Yu, H., Xu, D., Liang, Y., Rogaeva, E., Ikeda, M., Duthie, M., Murgolo, N., Wang, L., VanderVere, P., Bayne, M. L., Strader, C. D., Rommens, J. M., Fraser, P. E., & St. George-Hyslop, P. (1999). Presenilins interact with armadillo proteins including neural- specific plakophilin-related protein and β-catenin. Journal of Neurochemistry, 72(3), 999-1008. https://doi.org/10.1046/j.1471-4159.1999.0720999.x