Present and prospective clinical therapeutic regimens for Alzheimer's disease

Mustafa M. Husain, Kenneth Trevino, Haroon Siddique, Shawn M. McClintock

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Alzheimer's disease (AD) is an incurable neurodegenerative disorder that produces cognitive impairments that increase in severity as the disease progresses. The clinical symptoms are related to the presence of neuritic plaques and neurofibrillary tangles in the cerebral cortex which represent the pathophysiological hallmarks of AD. The debilitating nature of the disease can result in clinical burden for the patient, emotional strain for those that care for patients with Alzheimer's, and significant financial burden to society. The goals of current treatments, such as cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonist, are to reduce the severity or slow the progression of cognitive symptoms. Although these treatments have demonstrated modest clinical benefit, they are unable to prevent, prohibit, or reverse the underlying pathophysiology of AD. Considerable progress has been made toward the development of disease-modifying treatments. Treatments currently under development mainly target the production, aggregation, and removal of existing amyloid β-peptide aggregates which are believed to instigate the overall development of the neuropathology. Additional strategies that target tau pathology are being studied to promote neural protection against AD pathology. The current research has continued to expand our knowledge toward the development of disease modifying Alzheimer's therapies; however, no specific treatment strategy capable of demonstrating empirical efficacy and safety has yet to emerge.

Original languageEnglish (US)
Pages (from-to)765-777
Number of pages13
JournalNeuropsychiatric Disease and Treatment
Volume4
Issue number4
DOIs
StatePublished - Jan 1 2008

Keywords

  • Alzheimer's disease
  • Current treatments
  • Disease-modifying therapies
  • Pathophysiology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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