Preserved pancreatic β-cell development and function in mice lacking the insulin receptor-related receptor

T. Kitamura, Y. Kido, S. Nef, J. Merenmies, L. F. Parada, D. Accili

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Abstract

Receptors of the insulin/insulinlike growth factor (IGF) family have been implicated in the regulation of pancreatic β-cell growth and insulin secretion. The insulin receptor-related receptor (IRR) is an orphan receptor of the insulin receptor gene (Ir) subfamily. It is expressed at considerably higher levels in β cells than either insulin or IGF-1 receptors, and it has been shown to engage in heterodimer formation with insulin or IGF-1 receptors. To address whether IRR plays a physiologic role in β-cell development and regulation of insulin secretion, we have characterized mice lacking IRR and generated a combined knockout of Ir and Irr. We report that islet morphology, β-cell mass, and secretory function are not affected in IRR-deficient mice. Moreover, lack of IRR does not impair compensatory β-cell hyperplasia in insulin-resistant Ir+/- mice, nor does it affect β-cell development and function in Ir-/- mice. We conclude that glucose-stimulated insulin secretion and embryonic β-cell development occur normally in mice lacking Irr.

Original languageEnglish (US)
Pages (from-to)5624-5630
Number of pages7
JournalMolecular and Cellular Biology
Volume21
Issue number16
DOIs
StatePublished - 2001

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Insulin Receptor
Insulin
Growth Factor Receptors
Genes
Islets of Langerhans
Embryonic Development
Hyperplasia
insulin receptor-related receptor
Intercellular Signaling Peptides and Proteins
Glucose
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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Preserved pancreatic β-cell development and function in mice lacking the insulin receptor-related receptor. / Kitamura, T.; Kido, Y.; Nef, S.; Merenmies, J.; Parada, L. F.; Accili, D.

In: Molecular and Cellular Biology, Vol. 21, No. 16, 2001, p. 5624-5630.

Research output: Contribution to journalArticle

Kitamura, T. ; Kido, Y. ; Nef, S. ; Merenmies, J. ; Parada, L. F. ; Accili, D. / Preserved pancreatic β-cell development and function in mice lacking the insulin receptor-related receptor. In: Molecular and Cellular Biology. 2001 ; Vol. 21, No. 16. pp. 5624-5630.
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