Pressor response to endothelin in guinea pigs

L. Li, T. Ishikawa, T. Miyauchi, Masashi Yanagisawa, S. Kimura, K. Goto, T. Masaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Endothelin (ET), an endothelium-derived vasoconstrictor peptide, was injected into the jugular vein (i.v.) of guinea pigs anesthetized with urethane. Blood pressure was measured from a cannula inserted into the carotid artery. All experiments were carried out after treatment with adrenergic and cholinergic antagonists. ET showed a potent, dose-dependent pressor action in guinea pigs. However, the initial transient depressor response which is observed in rats was not produced in guinea pigs. Nicardipine (0.1 mg/kg), a dihydropyridine Ca2+-channel blocker, significantly inhibited the ET-induced pressor response. These results suggest that ET causes a potent response, which appears to be related to the activation of Ca2+ channels.

Original languageEnglish (US)
Pages (from-to)549-552
Number of pages4
JournalJapanese Journal of Pharmacology
Volume49
Issue number4
StatePublished - 1989

Fingerprint

Endothelins
Guinea Pigs
Nicardipine
Adrenergic Antagonists
Urethane
Jugular Veins
Cholinergic Antagonists
Vasoconstrictor Agents
Carotid Arteries
Endothelium
Blood Pressure
Peptides

ASJC Scopus subject areas

  • Pharmacology

Cite this

Li, L., Ishikawa, T., Miyauchi, T., Yanagisawa, M., Kimura, S., Goto, K., & Masaki, T. (1989). Pressor response to endothelin in guinea pigs. Japanese Journal of Pharmacology, 49(4), 549-552.

Pressor response to endothelin in guinea pigs. / Li, L.; Ishikawa, T.; Miyauchi, T.; Yanagisawa, Masashi; Kimura, S.; Goto, K.; Masaki, T.

In: Japanese Journal of Pharmacology, Vol. 49, No. 4, 1989, p. 549-552.

Research output: Contribution to journalArticle

Li, L, Ishikawa, T, Miyauchi, T, Yanagisawa, M, Kimura, S, Goto, K & Masaki, T 1989, 'Pressor response to endothelin in guinea pigs', Japanese Journal of Pharmacology, vol. 49, no. 4, pp. 549-552.
Li L, Ishikawa T, Miyauchi T, Yanagisawa M, Kimura S, Goto K et al. Pressor response to endothelin in guinea pigs. Japanese Journal of Pharmacology. 1989;49(4):549-552.
Li, L. ; Ishikawa, T. ; Miyauchi, T. ; Yanagisawa, Masashi ; Kimura, S. ; Goto, K. ; Masaki, T. / Pressor response to endothelin in guinea pigs. In: Japanese Journal of Pharmacology. 1989 ; Vol. 49, No. 4. pp. 549-552.
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