Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts

Wesley B. Baker, Ashwin B. Parthasarathy, Tiffany S. Ko, David R. Busch, Kenneth Abramson, Shih Yu Tzeng, Rickson C. Mesquita, Turgut Durduran, Joel H. Greenberg, David K. Kung, Arjun G. Yodh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The scheme determines subject-specific contributions of extracerebral and cerebral tissues to the DCS signal by utilizing probe pressure modulation to induce variations in extracerebral blood flow. For analysis, the head is modeled as a two-layer medium and is probed with long and short source-detector separations. Then a combination of pressure modulation and a modified Beer-Lambert law for flow enables experimenters to linearly relate differential DCS signals to cerebral and extracerebral blood flow variation without a priori anatomical information. We demonstrate the algorithm's ability to isolate cerebral blood flow during a finger-tapping task and during graded scalp ischemia in healthy adults. Finally, we adapt the pressure modulation algorithm to ameliorate extracerebral contamination in monitoring of cerebral blood oxygenation and blood volume by near-infrared spectroscopy.

Original languageEnglish (US)
Article number35004
JournalNeurophotonics
Volume2
Issue number3
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Artifacts
Hemodynamics
Pressure
Spectrum Analysis
Near-Infrared Spectroscopy
Blood Volume
Scalp
Fingers
Ischemia
Head

Keywords

  • cerebral blood flow monitoring
  • diffuse correlation spectroscopy
  • functional brain imaging
  • near-infrared spectroscopy
  • stroke

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Baker, W. B., Parthasarathy, A. B., Ko, T. S., Busch, D. R., Abramson, K., Tzeng, S. Y., ... Yodh, A. G. (2015). Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts. Neurophotonics, 2(3), [35004]. https://doi.org/10.1117/1.NPh.2.3.035004

Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts. / Baker, Wesley B.; Parthasarathy, Ashwin B.; Ko, Tiffany S.; Busch, David R.; Abramson, Kenneth; Tzeng, Shih Yu; Mesquita, Rickson C.; Durduran, Turgut; Greenberg, Joel H.; Kung, David K.; Yodh, Arjun G.

In: Neurophotonics, Vol. 2, No. 3, 35004, 01.07.2015.

Research output: Contribution to journalArticle

Baker, WB, Parthasarathy, AB, Ko, TS, Busch, DR, Abramson, K, Tzeng, SY, Mesquita, RC, Durduran, T, Greenberg, JH, Kung, DK & Yodh, AG 2015, 'Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts', Neurophotonics, vol. 2, no. 3, 35004. https://doi.org/10.1117/1.NPh.2.3.035004
Baker, Wesley B. ; Parthasarathy, Ashwin B. ; Ko, Tiffany S. ; Busch, David R. ; Abramson, Kenneth ; Tzeng, Shih Yu ; Mesquita, Rickson C. ; Durduran, Turgut ; Greenberg, Joel H. ; Kung, David K. ; Yodh, Arjun G. / Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts. In: Neurophotonics. 2015 ; Vol. 2, No. 3.
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