Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency

Brad Barker, Fevzi Altuntas, Geeta Paranjape, Ravindra Sarode

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post-exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery.

Original languageEnglish (US)
Pages (from-to)208-210
Number of pages3
JournalJournal of Clinical Apheresis
Volume19
Issue number4
DOIs
StatePublished - Dec 1 2004

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Keywords

  • Amyloidosis
  • Factor X deficiency
  • Plasma exchange

ASJC Scopus subject areas

  • Hematology

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