Presurgical plasma exchange is ineffective in correcting amyloid associated factor X deficiency

Brad Barker, Fevzi Altuntas, Geeta Paranjape, Ravindra Sarode

Research output: Contribution to journalArticle

9 Scopus citations


In patients with rare factor deficiencies, for which no factor concentrates are available, plasma exchange (PE) is an option for raising the desired factor level to approximately 80% for surgery. We report a case of acquired factor X (FX) deficiency due to amyloidosis that required urgent surgical repair of an AV fistula aneurysm. This patient had a FX level of 3% at presentation; after 1.5 volume PE with fresh frozen plasma (FFP), his post-exchange FX was only 5%, indicating rapid adsorption of FX to amyloid fibrils. He was managed successfully with FEIBA during surgery.

Original languageEnglish (US)
Pages (from-to)208-210
Number of pages3
JournalJournal of Clinical Apheresis
Issue number4
StatePublished - Dec 1 2004



  • Amyloidosis
  • Factor X deficiency
  • Plasma exchange

ASJC Scopus subject areas

  • Hematology

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