Presynaptic endoplasmic reticulum and neurotransmission

Ilya Bezprozvanny; Ege T. Kavalali

doi:10.1016/j.ceca.2019.102133

Presynaptic endoplasmic reticulum and neurotransmission

Ilya Bezprozvanny, Ege T. Kavalali

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Synaptic transmission relies on rapid calcium (Ca²⁺) influx into presynaptic terminal via voltage-gated Ca²⁺ channels. However, smooth ER is present in presynaptic terminals and accumulating evidence indicate that ER Ca²⁺ signaling may play a modulatory role in synaptic transmission. Most recent publication by Lindhout and colleagues (EMBO J, 38 (2019) e101345) suggested that the fragmentation state of the ER affects synaptic vesicle release. Here we discuss these results as well as several key publications that addressed a connection between ER Ca²⁺ signaling and synaptic transmission.

Original language	English (US)
Article number	102133
Journal	Cell Calcium
Volume	85
DOIs	https://doi.org/10.1016/j.ceca.2019.102133
State	Published - Jan 2020

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.ceca.2019.102133

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title = "Presynaptic endoplasmic reticulum and neurotransmission",

abstract = "Synaptic transmission relies on rapid calcium (Ca2+) influx into presynaptic terminal via voltage-gated Ca2+ channels. However, smooth ER is present in presynaptic terminals and accumulating evidence indicate that ER Ca2+ signaling may play a modulatory role in synaptic transmission. Most recent publication by Lindhout and colleagues (EMBO J, 38 (2019) e101345) suggested that the fragmentation state of the ER affects synaptic vesicle release. Here we discuss these results as well as several key publications that addressed a connection between ER Ca2+ signaling and synaptic transmission.",

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AU - Kavalali, Ege T.

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AB - Synaptic transmission relies on rapid calcium (Ca2+) influx into presynaptic terminal via voltage-gated Ca2+ channels. However, smooth ER is present in presynaptic terminals and accumulating evidence indicate that ER Ca2+ signaling may play a modulatory role in synaptic transmission. Most recent publication by Lindhout and colleagues (EMBO J, 38 (2019) e101345) suggested that the fragmentation state of the ER affects synaptic vesicle release. Here we discuss these results as well as several key publications that addressed a connection between ER Ca2+ signaling and synaptic transmission.

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Presynaptic endoplasmic reticulum and neurotransmission

Abstract

ASJC Scopus subject areas

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