Presynaptic nicotinic receptors facilitate monoaminergic transmission

Xiangyang Li, Donald G. Rainnie, Robert W. McCarley, Robert W. Greene

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Nicotine is reported to increase arousal and attention and to elevate mood, effects that are most often associated with changes in the function of monoaminergic neuromodulatory systems (Feldman et al., 1997). Recent studies have shown a nicotinic receptor-mediated presynaptic enhancement of fast glutamatergic (McGehee et al., 1995; Gray et al., 1996) and GABAergic (Lena and Changeux, 1997) transmission. However, the mechanism of nicotinic effects on metabotropic-mediated transmission in general, and on monoaminergic transmission in particular, is less well understood. We have examined nicotinic effects on dorsal raphe neurons of rats using whole-cell current and voltage-clamp recording techniques in vitro. In the majority of these neurons, activation of presynaptic nicotinic receptors induced a depolarization mediated by norepinephrine acting on α1 receptors. Blockade of this response revealed a hyperpolarization mediated by serotonin acting on 5-HT(1A) receptors. Because the norepinephrine effect was sensitive to methyllycaconitine (100 nM), it is concluded that nicotinic receptors with an α7 subunit can facilitate release of norepinephrine to activate metabotropic receptors. In contrast, methyllycaconitine-insensitive nicotinic receptors can induce 5-HT release in the dorsal raphe nucleus.

Original languageEnglish (US)
Pages (from-to)1904-1912
Number of pages9
JournalJournal of Neuroscience
Volume18
Issue number5
StatePublished - Mar 1 1998

Fingerprint

Presynaptic Receptors
Nicotinic Receptors
Norepinephrine
Cholinergic Agents
Serotonin
Neurons
Receptor, Serotonin, 5-HT1A
Patch-Clamp Techniques
Arousal
Nicotine
Dorsal Raphe Nucleus
methyllycaconitine

Keywords

  • Acetylcholine
  • Dorsal raphe
  • Electrophysiology
  • Methyllycaconitine
  • Norepinephrine
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Presynaptic nicotinic receptors facilitate monoaminergic transmission. / Li, Xiangyang; Rainnie, Donald G.; McCarley, Robert W.; Greene, Robert W.

In: Journal of Neuroscience, Vol. 18, No. 5, 01.03.1998, p. 1904-1912.

Research output: Contribution to journalArticle

Li, X, Rainnie, DG, McCarley, RW & Greene, RW 1998, 'Presynaptic nicotinic receptors facilitate monoaminergic transmission', Journal of Neuroscience, vol. 18, no. 5, pp. 1904-1912.
Li, Xiangyang ; Rainnie, Donald G. ; McCarley, Robert W. ; Greene, Robert W. / Presynaptic nicotinic receptors facilitate monoaminergic transmission. In: Journal of Neuroscience. 1998 ; Vol. 18, No. 5. pp. 1904-1912.
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