Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation

D. A. Horak, G. M. Schmidt, J. A. Zaia, J. C. Niland, C. Ahn, S. J. Forman

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Study Objective: To determine the value of pulmonary function tests (PFTs) in predicting the development of human cytomegalovirus (CMV)-associated interstitial pneumonia (IP) in allogeneic bone marrow transplant (BMT) recipients. Design: Nonrandomized, prospective, open-trial study. Setting: Tertiary referral medical center. Patients: 66 evaluable CMV-seropositive patients with hematologic malignancies who were undergoing allogeneic BMT. Intervention: FEV1, FVC, FEV1/FVC, TLC, Dco(c)/VA, PaO2, and P(A-a)O2 were measured on days -13, +33, and +44 following BMT. CMV-IP was diagnosed when typical roentgenographic findings developed with confirmatory positive bronchoalveolar lavage (BAL) using standard cytologic and/or rapid culture techniques. Measurement and Main Results: Univariate logistic regression analysis to predict the development of CMV-IP revealed significant associations with the day -13 and +33 percent predicted FEV1, FVC, and TLC (p<0.01) but no associations with other PFT parameters or with changes in these parameters. Stepwise logistic regression analysis demonstrated that only BAL positivity for CMV (odds ratio 14.8; p = 0.0002) and day -13 percent predicted FEV1 (odds ratio 0.92; p = 0.0004) were significant independent predictors of CMV-IP. Conclusion: Pretransplant lung function is a previously unrecognized strong predictor and risk factor for the subsequent development of CMV-IP in BMT recipients.

Original languageEnglish (US)
Pages (from-to)1484-1490
Number of pages7
JournalChest
Volume102
Issue number5
StatePublished - 1992

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Interstitial Lung Diseases
Cytomegalovirus
Bone Marrow Transplantation
Lung
Bone Marrow
Respiratory Function Tests
Bronchoalveolar Lavage
Logistic Models
Odds Ratio
Regression Analysis
Transplants
Culture Techniques
Human Development
Hematologic Neoplasms
Tertiary Care Centers

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Horak, D. A., Schmidt, G. M., Zaia, J. A., Niland, J. C., Ahn, C., & Forman, S. J. (1992). Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation. Chest, 102(5), 1484-1490.

Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation. / Horak, D. A.; Schmidt, G. M.; Zaia, J. A.; Niland, J. C.; Ahn, C.; Forman, S. J.

In: Chest, Vol. 102, No. 5, 1992, p. 1484-1490.

Research output: Contribution to journalArticle

Horak, DA, Schmidt, GM, Zaia, JA, Niland, JC, Ahn, C & Forman, SJ 1992, 'Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation', Chest, vol. 102, no. 5, pp. 1484-1490.
Horak, D. A. ; Schmidt, G. M. ; Zaia, J. A. ; Niland, J. C. ; Ahn, C. ; Forman, S. J. / Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation. In: Chest. 1992 ; Vol. 102, No. 5. pp. 1484-1490.
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