Prevalence of abdominal aortic calcifications in older living renal donors and its effect on graft function and histology

En Haw Wu, David Wojciechowski, Sindhu Chandran, Benjamin M. Yeh, Meyeon Park, Antonio Westphalen, Zhen J. Wang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We assessed the prevalence of abdominal aortic calcification (AAC) in older living kidney donors and its effect on recipient eGFR and graft histology. A total of 292 consecutive living pairs with donor age ≥50 from 2003 to 2013 were identified (mean age 56; range 50-78; F/M: 1.8). Donor AAC was determined by prenephrectomy unenhanced CT. Recipient eGFR and spot urine protein: creatinine ratios (UPCRs) were recorded. A total of 180 recipients had 6-month protocol biopsies. AAC was present in 40.7% of donors, and they were older (58.6 versus 54.7 years old, P < 0.0001) and more likely to be male (77.6% vs. 37.3%, P = 0.004). There was no significant difference in eGFR or spot UPCR up to 36 months in recipients of allografts from donors with versus without AAC. At 6-month biopsy, there was a higher percentage of allografts with vascular fibrous intimal thickening and arteriolar hyaline thickening from donors with versus without AAC (vascular fibrous intimal thickening: 38.8% vs. 7.1% and arteriolar hyaline thickening: 35.8% vs. 7.1%; P < 0.001 for both). The presence of donor AAC predicts the presence of vascular disease [vascular fibrous intimal thickening (OR: 7.2; CI:2.9-17.9) and arteriolar hyaline thickening (OR:5.7; CI:2.3-14.1)] in allografts at 6 months. Donor AAC is predictive of renal vascular disease and may help to improve the screening of potential donors and inform post-transplant management.

Original languageEnglish (US)
Pages (from-to)1172-1178
Number of pages7
JournalTransplant International
Volume28
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Keywords

  • imaging
  • kidney clinical
  • live donors
  • outcome

ASJC Scopus subject areas

  • Transplantation

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