TY - JOUR
T1 - Prevalence of antibodies against orthopoxviruses among residents of Likouala region, Republic of Congo
T2 - Evidence for Monkeypox virus exposure
AU - Lederman, Edith R.
AU - Reynolds, Mary G.
AU - Karem, Kevin
AU - Braden, Zachary
AU - Learned-Orozco, Lynne A.
AU - Wassa-Wassa, Demole
AU - Moundeli, Omba
AU - Hughes, Christine
AU - Harvey, Joseph
AU - Regnery, Russell
AU - Mombouli, Jean Vivien
AU - Damon, Inger K.
PY - 2007/12
Y1 - 2007/12
N2 - Monkeypox virus is a zoonotic orthopoxvirus (OPX) of west and central sub-Saharan Africa. We conducted a cross-sectional serosurvey in Likouala region, Republic of Congo to assess exposure to OPX. Whole blood was collected using Nobuto blood filter strips (NBFS). Titers of IgM and IgG to OPX were assessed using an enzyme-linked immunosorbent assay. Demographic and clinical characteristics were compared with serostatus using the chi-square test or Fisher's exact test. Multivariate logistic regression was performed to evaluate factors for independent association with serostatus. A total of 994 specimens were analyzed; the overall seroprevalence for OPX IgM was 1.7%. Age < 25 years reduced the likelihood of OPX exposure, and persons living in Ngangania village had independently higher odds (odds ratio = 33.5, 95% confidence interval = 7.2-166). Blood collection for serosurveys using NBFS is feasible and practical. Adult activities such as hunting and carcass preparation may play an important role in exposure to Monkeypox virus.
AB - Monkeypox virus is a zoonotic orthopoxvirus (OPX) of west and central sub-Saharan Africa. We conducted a cross-sectional serosurvey in Likouala region, Republic of Congo to assess exposure to OPX. Whole blood was collected using Nobuto blood filter strips (NBFS). Titers of IgM and IgG to OPX were assessed using an enzyme-linked immunosorbent assay. Demographic and clinical characteristics were compared with serostatus using the chi-square test or Fisher's exact test. Multivariate logistic regression was performed to evaluate factors for independent association with serostatus. A total of 994 specimens were analyzed; the overall seroprevalence for OPX IgM was 1.7%. Age < 25 years reduced the likelihood of OPX exposure, and persons living in Ngangania village had independently higher odds (odds ratio = 33.5, 95% confidence interval = 7.2-166). Blood collection for serosurveys using NBFS is feasible and practical. Adult activities such as hunting and carcass preparation may play an important role in exposure to Monkeypox virus.
UR - http://www.scopus.com/inward/record.url?scp=39049126181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39049126181&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2007.77.1150
DO - 10.4269/ajtmh.2007.77.1150
M3 - Article
C2 - 18165539
AN - SCOPUS:39049126181
SN - 0002-9637
VL - 77
SP - 1150
EP - 1156
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 6
ER -