TY - JOUR
T1 - Prevalence of human papillomavirus genotypes and related abnormalities of cervical cytological results among HIV-1-infected women in Rochester, New York
AU - Luque, Amneris E.
AU - Jabeen, Musaret
AU - Messing, Susan
AU - Lane, Christopher A.
AU - Demeter, Lisa M.
AU - Rose, Robert C.
AU - Reichman, Richard C.
N1 - Funding Information:
Received 7 November 2005; accepted 7 April 2006; electronically published 13 July 2006. Presented in part: XVth International AIDS Conference, Bangkok, Thailand, 11– 16 July 2004 (abstract MoPeB3323). Potential conflicts of interest: none reported. Financial support: National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH; grants UO1-AI-27658 and N01-AI-38858); NIH (grant 5PO1HD040540); National Center for Research Resources, NIH (general clinical research center grant 5 MO1 RR 00044); National Institute of Child Health and Human Development, NIH (grant HD-00-007). a Present affiliation: Heart and Lung Institute, Salt Lake City, Utah. Reprints or correspondence: Dr. Amneris E. Luque, University of Rochester Medical Center, Box 689, 601 Elmwood Ave., Rochester, NY 14642 (amneris_luque@ urmc.rochester.edu).
PY - 2006/8/15
Y1 - 2006/8/15
N2 - Women with human immunodeficiency virus (HIV) infection have higher rates of concurrent human papillomavirus (HPV) infection and cervical dysplasia than do HIV-uninfected women. They are also more commonly infected with multiple HPV types simultaneously. To determine the prevalence of different HPV genotypes in a group of HIV-infected women and to correlate these findings with cervical cytological results, we studied a group of 229 women attending a university-based HIV clinic during a 7-year period. When cervicovaginal lavage specimens, the reverse line-blot assay, and DNA sequencing were used, the most commonly detected HPV types (in decreasing order of frequency) were 56, 53, 16, 58, 52, MM7, MM8, and 33. These results contrast sharply with similar studies of HIV-uninfected women, in whom HPV-16 and -18 generally predominate. In our study, the HPV types most commonly associated with low-grade squamous intraepithelial lesions (SILs) were 56 and 53. Types most commonly associated with high-grade SILs were 52 and 58. High-risk HPV types other than 16 and 18 are often found in HIV-infected women and are frequently associated with abnormal cervical cytological results in this setting. These observations have implications for the design of future HPV vaccines.
AB - Women with human immunodeficiency virus (HIV) infection have higher rates of concurrent human papillomavirus (HPV) infection and cervical dysplasia than do HIV-uninfected women. They are also more commonly infected with multiple HPV types simultaneously. To determine the prevalence of different HPV genotypes in a group of HIV-infected women and to correlate these findings with cervical cytological results, we studied a group of 229 women attending a university-based HIV clinic during a 7-year period. When cervicovaginal lavage specimens, the reverse line-blot assay, and DNA sequencing were used, the most commonly detected HPV types (in decreasing order of frequency) were 56, 53, 16, 58, 52, MM7, MM8, and 33. These results contrast sharply with similar studies of HIV-uninfected women, in whom HPV-16 and -18 generally predominate. In our study, the HPV types most commonly associated with low-grade squamous intraepithelial lesions (SILs) were 56 and 53. Types most commonly associated with high-grade SILs were 52 and 58. High-risk HPV types other than 16 and 18 are often found in HIV-infected women and are frequently associated with abnormal cervical cytological results in this setting. These observations have implications for the design of future HPV vaccines.
UR - http://www.scopus.com/inward/record.url?scp=33746722064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746722064&partnerID=8YFLogxK
U2 - 10.1086/505876
DO - 10.1086/505876
M3 - Article
C2 - 16845625
AN - SCOPUS:33746722064
SN - 0022-1899
VL - 194
SP - 428
EP - 434
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -