Prevalence, risk factors, and molecular epidemiology of methicillin-resistant Staphylococcus aureus nasal and axillary colonization among psychiatric patients on admission to an academic medical center

Jason E. Farley, Tracy Ross, Jenna Krall, Matt Hayat, Ann Caston-Gaa, Trish Perl, Karen C. Carroll

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Infection control data from psychiatric units and clinics are limited. Methods: This time series study was designed to determine the prevalence and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) colonization and/or infection among 500 men and women on admission to psychiatric units at The Johns Hopkins Hospital. Discharge surveillance was conducted to measure incidence. Molecular characterization was performed. Results: Five hundred subjects (52% male) were enrolled. The prevalence of MRSA colonization was 5.2% (26 of 498). Seven of 29 patients (24.1%) admitted with a skin and soft tissue infection (SSTI) was MRSA-positive; 4 of these patients had no other positive site, raising the total admission prevalence to 6.0%. A history of abscess (current or within the past 6 months) on admission (odds ratio [OR], 6.06; 95% confidence interval [CI], 2.40-15.31; P < .001), HIV infection (OR, 4.03; 95% CI, 1.52-10.71; P = .005), previous isolation (OR, 5.03; 95% CI, 1.76-14.35; P = .003), and unknown history of isolation (OR, 4.10; 95% CI, 1.41-11.98; P = .01) were associated with increased odds of MRSA colonization. Seven (2.6%) new MRSA colonizations were identified at discharge. Molecular analysis identified USA300 clonal MRSA isolates. Conclusions: The prevalence of MRSA colonization in this study population was greater than reported in the general population. Further studies are needed to identify transmission dynamics in this environment.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalAmerican Journal of Infection Control
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2013

Fingerprint

Molecular Epidemiology
Patient Admission
Methicillin-Resistant Staphylococcus aureus
Nose
Psychiatry
Odds Ratio
Confidence Intervals
Soft Tissue Infections
Infection Control
Abscess
Population
HIV Infections
Skin
Incidence
Infection

Keywords

  • Colonization
  • Infection control
  • Mental health
  • Methicillin resistant Staphylococcus aureas
  • Psychiatry

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Health Policy

Cite this

Prevalence, risk factors, and molecular epidemiology of methicillin-resistant Staphylococcus aureus nasal and axillary colonization among psychiatric patients on admission to an academic medical center. / Farley, Jason E.; Ross, Tracy; Krall, Jenna; Hayat, Matt; Caston-Gaa, Ann; Perl, Trish; Carroll, Karen C.

In: American Journal of Infection Control, Vol. 41, No. 3, 01.03.2013, p. 199-203.

Research output: Contribution to journalArticle

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abstract = "Background: Infection control data from psychiatric units and clinics are limited. Methods: This time series study was designed to determine the prevalence and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) colonization and/or infection among 500 men and women on admission to psychiatric units at The Johns Hopkins Hospital. Discharge surveillance was conducted to measure incidence. Molecular characterization was performed. Results: Five hundred subjects (52{\%} male) were enrolled. The prevalence of MRSA colonization was 5.2{\%} (26 of 498). Seven of 29 patients (24.1{\%}) admitted with a skin and soft tissue infection (SSTI) was MRSA-positive; 4 of these patients had no other positive site, raising the total admission prevalence to 6.0{\%}. A history of abscess (current or within the past 6 months) on admission (odds ratio [OR], 6.06; 95{\%} confidence interval [CI], 2.40-15.31; P < .001), HIV infection (OR, 4.03; 95{\%} CI, 1.52-10.71; P = .005), previous isolation (OR, 5.03; 95{\%} CI, 1.76-14.35; P = .003), and unknown history of isolation (OR, 4.10; 95{\%} CI, 1.41-11.98; P = .01) were associated with increased odds of MRSA colonization. Seven (2.6{\%}) new MRSA colonizations were identified at discharge. Molecular analysis identified USA300 clonal MRSA isolates. Conclusions: The prevalence of MRSA colonization in this study population was greater than reported in the general population. Further studies are needed to identify transmission dynamics in this environment.",
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