Preventing mediastinal shift after pneumonectomy does not abolish physiological compensation

E. Y. Wu, C. C W Hsia, A. S. Estrera, R. H. Epstein, M. Ramanathan, R. L. Johnson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

To determine the role of mediastinal shift after pneumonectomy (PNX) on compensatory responses, we performed right PNX in adult dogs and replaced the resected lung with a custom- shaped inflatable silicone prosthesis. Prosthesis was inflated (Inf) to prevent mediastinal shift, or deflated (Def), allowing mediastinal shift to occur. Thoracic, lung air, and tissue volumes were measured by computerized tomography scan. Lung diffusing capacities for carbon monoxide (DL(CO)) and its components, membrane diffusing capacity for carbon monoxide (Dm(CO)) and capillary blood volume (Vc), were measured at rest and during exercise by a rebreathing technique. In the Inf group, lung air volume was significantly smaller than in Def group; however, the lung became elongated and expanded by 20% via caudal displacement of the left hemidiaphragm. Consequently, rib cage volume was similar, but total thoracic volume was higher in the Inf group. Extravascular septal tissue volume was not different between groups. At a given pulmonary blood flow, DL(CO) and Dm(CO) were significantly lower in the Inf group, but Vc was similar. In one dog, delayed mediastinal shift occurred 9 mo after PNX; both lung volume and DL(CO) progressively increased over the subsequent 3 mo. We conclude that preventing mediastinal shift after PNX impairs recruitment of diffusing capacity but does not abolish expansion of the remaining lung or the compensatory increase in extravascular septal tissue volume.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalJournal of Applied Physiology
Volume89
Issue number1
StatePublished - Jul 2000

Fingerprint

Pneumonectomy
Carbon Monoxide
Lung
Prostheses and Implants
Thorax
Air
Dogs
Lung Volume Measurements
Silicones
Blood Volume
Tomography
Membranes

Keywords

  • Dog
  • Exercise
  • Gas exchange
  • Lung strain
  • Membrane diffusing capacity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Wu, E. Y., Hsia, C. C. W., Estrera, A. S., Epstein, R. H., Ramanathan, M., & Johnson, R. L. (2000). Preventing mediastinal shift after pneumonectomy does not abolish physiological compensation. Journal of Applied Physiology, 89(1), 182-191.

Preventing mediastinal shift after pneumonectomy does not abolish physiological compensation. / Wu, E. Y.; Hsia, C. C W; Estrera, A. S.; Epstein, R. H.; Ramanathan, M.; Johnson, R. L.

In: Journal of Applied Physiology, Vol. 89, No. 1, 07.2000, p. 182-191.

Research output: Contribution to journalArticle

Wu, EY, Hsia, CCW, Estrera, AS, Epstein, RH, Ramanathan, M & Johnson, RL 2000, 'Preventing mediastinal shift after pneumonectomy does not abolish physiological compensation', Journal of Applied Physiology, vol. 89, no. 1, pp. 182-191.
Wu, E. Y. ; Hsia, C. C W ; Estrera, A. S. ; Epstein, R. H. ; Ramanathan, M. ; Johnson, R. L. / Preventing mediastinal shift after pneumonectomy does not abolish physiological compensation. In: Journal of Applied Physiology. 2000 ; Vol. 89, No. 1. pp. 182-191.
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