TY - JOUR
T1 - Prevention of atherosclerotic cardiovascular disease in South Asians in the US
T2 - A clinical perspective from the National Lipid Association: Prevention of ASCVD in SAUS
AU - Kalra, Dinesh
AU - Vijayaraghavan, Krishnaswami
AU - Sikand, Geeta
AU - Desai, Nihar R.
AU - Joshi, Parag H.
AU - Mehta, Anurag
AU - Karmally, Wahida
AU - Vani, Anish
AU - Sitafalwalla, Shoeb J.
AU - Puri, Raman
AU - Duell, P. Barton
AU - Brown, Alan
N1 - Funding Information:
The National Lipid Association (NLA) Expert Panel wishes to express its gratitude to the following individuals, whose assistance was invaluable in preparation of these recommendations: Terry A. Jacobson, MD (Emory University, Atlanta, GA, USA), Kevin C. Maki, PhD (Indiana University School of Public Health, Bloomington, IN, USA), Mary R. Dicklin, PhD (Midwest Biomedical Research, Addison, IL, USA), Neel Jani, PharmD (Amgen, Thousand Oaks, CA, USA).
Publisher Copyright:
© 2021
PY - 2021/5/1
Y1 - 2021/5/1
N2 - It is now well recognized that South Asians living in the US (SAUS) have a higher prevalence of atherosclerotic cardiovascular disease (ASCVD) that begins earlier and is more aggressive than age-matched people of other ethnicities. SA ancestry is now recognized as a risk enhancer in the US cholesterol treatment guidelines. The pathophysiology of this is not fully understood but may relate to insulin resistance, genetic and dietary factors, lack of physical exercise, visceral adiposity and other, yet undiscovered biologic mechanisms. In this expert consensus document, we review the epidemiology of ASCVD in this population, enumerate the challenges faced in tackling this problem, provide strategies for early screening and education of the community and their healthcare providers, and offer practical prevention strategies and culturally-tailored dietary advice to lower the rates of ASCVD in this cohort.
AB - It is now well recognized that South Asians living in the US (SAUS) have a higher prevalence of atherosclerotic cardiovascular disease (ASCVD) that begins earlier and is more aggressive than age-matched people of other ethnicities. SA ancestry is now recognized as a risk enhancer in the US cholesterol treatment guidelines. The pathophysiology of this is not fully understood but may relate to insulin resistance, genetic and dietary factors, lack of physical exercise, visceral adiposity and other, yet undiscovered biologic mechanisms. In this expert consensus document, we review the epidemiology of ASCVD in this population, enumerate the challenges faced in tackling this problem, provide strategies for early screening and education of the community and their healthcare providers, and offer practical prevention strategies and culturally-tailored dietary advice to lower the rates of ASCVD in this cohort.
KW - Atherosclerotic cardiovascular disease
KW - Coronary artery disease
KW - Genetics
KW - Lifestyle
KW - Lp(a)
KW - Metabolic syndrome
KW - Myocardial infarction
KW - Primary prevention
KW - Scientific statement
KW - South Asian
KW - Treatment
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U2 - 10.1016/j.jacl.2021.03.007
DO - 10.1016/j.jacl.2021.03.007
M3 - Article
C2 - 33846108
AN - SCOPUS:85103968432
SN - 1933-2874
VL - 15
SP - 402
EP - 422
JO - Journal of Clinical Lipidology
JF - Journal of Clinical Lipidology
IS - 3
ER -