Prevention of coronary heart disease through cholesterol reduction

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Growing evidence suggests that lowering serum cholesterol levels, particularly low-density lipoprotein levels, will reduce the risk for coronary heart disease. The benefit of cholesterol-lowering therapy has been documented by many clinical trials. Two secondary prevention trials, the Scandinavian Simvastatin Survival Study and the Cholesterol and Recurrent Events trial, demonstrated a striking reduction in recurrent coronary heart disease without an increase in noncardiovascular mortality; treatment with simvastatin reduced total mortality by 30 percent. A primary prevention trial, the West of Scotland Coronary Prevention Study, demonstrated similar results in high-risk patients without established coronary heart disease. More recent angiographic trials revealed that cholesterol-lowering therapy will reduce progression of atherosclerosis and, in some cases, will reverse existing lesions. Use of HMG-CoA reductase inhibitors also appears to be beneficial and safe. Evidence supports cholesterol-lowering therapy in high- risk patients, both with and without established atherosclerotic disease.

Original languageEnglish (US)
Pages (from-to)2250-2258
Number of pages9
JournalAmerican Family Physician
Volume55
Issue number6
StatePublished - May 1 1997

ASJC Scopus subject areas

  • Family Practice

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