Prevence reakce štěpu proti hostiteli u pacientů podstupujících alogenní transplantaci hematopoetických kmenových buněk pomocí anti-CD25 imunotoxinu

Translated title of the contribution: Prevention of graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation using an anti-CD25 immunotoxin

Research output: Contribution to journalReview article

Abstract

Graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation. Donor T cells play major role in GVHD leading to the host tissue damage, mainly of the skin, liver, and gastrointestinal tract. T cell depletion leads to a decreasing risk of GVHD but also to an increasing risk of opportunistic infections, a relapse of the underlying disease, and a graft rejection. The selective depletion using an anti-CD25 immunotoxin can eliminate harmful alloreactive T cells while preserving other donor T cells with antileukemic and antibacterial reactivity. This review summarizes preclinical testing of the anti-CD25 immunotoxin performed by the authors and presents general characteristics of immunotoxins in anticancer therapy.

Translated title of the contributionPrevention of graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation using an anti-CD25 immunotoxin
Original languageCzech
Pages (from-to)134-137
Number of pages4
JournalKlinicka Onkologie
Volume16
Issue number3
StatePublished - Aug 27 2003

Keywords

  • Graft-versus-host disease
  • Immunotoxin
  • T cell
  • Transplantation

ASJC Scopus subject areas

  • Oncology

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