Prevence reakce štěpu proti hostiteli u pacientů podstupujících alogenní transplantaci hematopoetických kmenových buněk pomocí anti-CD25 imunotoxinu

Translated title of the contribution: Prevention of graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation using an anti-CD25 immunotoxin

Research output: Contribution to journalArticle

Abstract

Graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation. Donor T cells play major role in GVHD leading to the host tissue damage, mainly of the skin, liver, and gastrointestinal tract. T cell depletion leads to a decreasing risk of GVHD but also to an increasing risk of opportunistic infections, a relapse of the underlying disease, and a graft rejection. The selective depletion using an anti-CD25 immunotoxin can eliminate harmful alloreactive T cells while preserving other donor T cells with antileukemic and antibacterial reactivity. This review summarizes preclinical testing of the anti-CD25 immunotoxin performed by the authors and presents general characteristics of immunotoxins in anticancer therapy.

Original languageUndefined
Pages (from-to)134-137
Number of pages4
JournalKlinicka Onkologie
Volume16
Issue number3
StatePublished - 2003

Fingerprint

Immunotoxins
Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
T-Lymphocytes
Tissue Donors
Opportunistic Infections
Graft Rejection
Stem Cell Transplantation
Gastrointestinal Tract
Recurrence
Skin
Liver
Therapeutics

Keywords

  • Graft-versus-host disease
  • Immunotoxin
  • T cell
  • Transplantation

ASJC Scopus subject areas

  • Oncology

Cite this

@article{fcd3a3455f0346d38428de754adcba0f,
title = "Prevence reakce štěpu proti hostiteli u pacientů podstupuj{\'i}c{\'i}ch alogenn{\'i} transplantaci hematopoetick{\'y}ch kmenov{\'y}ch buněk pomoc{\'i} anti-CD25 imunotoxinu",
abstract = "Graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation. Donor T cells play major role in GVHD leading to the host tissue damage, mainly of the skin, liver, and gastrointestinal tract. T cell depletion leads to a decreasing risk of GVHD but also to an increasing risk of opportunistic infections, a relapse of the underlying disease, and a graft rejection. The selective depletion using an anti-CD25 immunotoxin can eliminate harmful alloreactive T cells while preserving other donor T cells with antileukemic and antibacterial reactivity. This review summarizes preclinical testing of the anti-CD25 immunotoxin performed by the authors and presents general characteristics of immunotoxins in anticancer therapy.",
keywords = "Graft-versus-host disease, Immunotoxin, T cell, Transplantation",
author = "J. Mich{\'a}lek and Collins, {R. H.} and Vitetta, {E. S.}",
year = "2003",
language = "Undefined",
volume = "16",
pages = "134--137",
journal = "Klinicka Onkologie",
issn = "0862-495X",
publisher = "Ceska Lekarska Spolecnost J.E. Purkyne/Czech Medical Association of J.E. Purkyne",
number = "3",

}

TY - JOUR

T1 - Prevence reakce štěpu proti hostiteli u pacientů podstupujících alogenní transplantaci hematopoetických kmenových buněk pomocí anti-CD25 imunotoxinu

AU - Michálek, J.

AU - Collins, R. H.

AU - Vitetta, E. S.

PY - 2003

Y1 - 2003

N2 - Graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation. Donor T cells play major role in GVHD leading to the host tissue damage, mainly of the skin, liver, and gastrointestinal tract. T cell depletion leads to a decreasing risk of GVHD but also to an increasing risk of opportunistic infections, a relapse of the underlying disease, and a graft rejection. The selective depletion using an anti-CD25 immunotoxin can eliminate harmful alloreactive T cells while preserving other donor T cells with antileukemic and antibacterial reactivity. This review summarizes preclinical testing of the anti-CD25 immunotoxin performed by the authors and presents general characteristics of immunotoxins in anticancer therapy.

AB - Graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation. Donor T cells play major role in GVHD leading to the host tissue damage, mainly of the skin, liver, and gastrointestinal tract. T cell depletion leads to a decreasing risk of GVHD but also to an increasing risk of opportunistic infections, a relapse of the underlying disease, and a graft rejection. The selective depletion using an anti-CD25 immunotoxin can eliminate harmful alloreactive T cells while preserving other donor T cells with antileukemic and antibacterial reactivity. This review summarizes preclinical testing of the anti-CD25 immunotoxin performed by the authors and presents general characteristics of immunotoxins in anticancer therapy.

KW - Graft-versus-host disease

KW - Immunotoxin

KW - T cell

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=0043025204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043025204&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 134

EP - 137

JO - Klinicka Onkologie

JF - Klinicka Onkologie

SN - 0862-495X

IS - 3

ER -