Prevention of Preeclampsia and Eclampsia

Baha M. Sibai, F. Gary Cunningham

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Abstract

The precise pathogenesis of convulsions with the preeclampsia syndrome is enigmatic, the two prevailing schemes are vasospasm with ischemia and hypertensive encephalopathy. Eclampsia prevention can be primary by preventing worsening of preeclampsia; it can be secondary by using agents to prevent convulsions in women with established preeclampsia; and it can be tertiary by preventing recurrent convulsions in women with eclampsia. The decision to use secondary prophylaxis would in some regards depend on the likelihood of eclamptic convulsions in women with preeclampsia. Thus the use Magnesium Sulfate is used in mild and severe preeclampsia. The primary objective of magnesium sulfate prophylaxis in women with preeclampsia is to prevent or reduce the rate of eclampsia and associated complications. Other benefits include reduced maternal and perinatal mortalities and morbidities. In addition, in women with mild preeclampsia, a secondary benefit might include a decreased rate of progression to severe preeclampsia.

Original languageEnglish (US)
Title of host publicationChesley's Hypertensive Disorders in Pregnancy
PublisherElsevier Inc.
Pages213-225
Number of pages13
ISBN (Print)9780123742131
DOIs
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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    Sibai, B. M., & Gary Cunningham, F. (2009). Prevention of Preeclampsia and Eclampsia. In Chesley's Hypertensive Disorders in Pregnancy (pp. 213-225). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374213-1.00012-4