Prevention of preeclampsia and eclampsia

Anne Cathrine Staff, Baha M. Sibai, F. Gary Cunningham

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

There have been many randomized trials to determine whether preeclampsia/eclampsia, a major cause of maternal and perinatal mortality and morbidity, can be prevented. Most were designed to evaluate whether low-dose aspirin regimens prevent preeclampsia. The results subjected to meta-analysis revealed a 10% reduction in the incidence of preeclampsia in women assigned low-dose aspirin, but very little improvement in morbid outcomes. There were least 10 randomized trials in which prevention by calcium supplementation (1.5 to 2 g/d) was evaluated, their results subjected to two systematic reviews whose conclusions conflict. Other trials evaluated use of fish oil or vitamins C and E supplementation for the prevention of preeclampsia in low- and high-risk pregnant women. Through 2013 these latter studies have all been negative. There have also been randomized trials evaluating use of magnesium sulfate to prevent eclampsia, demonstrating a reduction in the rate of seizures by one half.

Original languageEnglish (US)
Title of host publicationChesley's Hypertensive Disorders in Pregnancy, Fourth Edition
PublisherElsevier Science
Pages253-267
Number of pages15
ISBN (Electronic)9780124078666
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Antioxidants
  • Calcium supplementation
  • Eclampsia
  • Low-dose aspirin
  • Magnesium sulfate
  • Preeclampsia
  • Prevention

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Staff, A. C., Sibai, B. M., & Gary Cunningham, F. (2014). Prevention of preeclampsia and eclampsia. In Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition (pp. 253-267). Elsevier Science. https://doi.org/10.1016/B978-0-12-407866-6.00012-2