Prevention of preeclampsia and eclampsia

Anne Cathrine Staff, Baha M. Sibai, F. Gary Cunningham

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


There have been many randomized trials to determine whether preeclampsia/eclampsia, a major cause of maternal and perinatal mortality and morbidity, can be prevented. Most were designed to evaluate whether low-dose aspirin regimens prevent preeclampsia. The results subjected to meta-analysis revealed a 10% reduction in the incidence of preeclampsia in women assigned low-dose aspirin, but very little improvement in morbid outcomes. There were least 10 randomized trials in which prevention by calcium supplementation (1.5 to 2 g/d) was evaluated, their results subjected to two systematic reviews whose conclusions conflict. Other trials evaluated use of fish oil or vitamins C and E supplementation for the prevention of preeclampsia in low- and high-risk pregnant women. Through 2013 these latter studies have all been negative. There have also been randomized trials evaluating use of magnesium sulfate to prevent eclampsia, demonstrating a reduction in the rate of seizures by one half.

Original languageEnglish (US)
Title of host publicationChesley's Hypertensive Disorders in Pregnancy, Fourth Edition
PublisherElsevier Science
Number of pages15
ISBN (Electronic)9780124078666
Publication statusPublished - Jan 1 2014



  • Antioxidants
  • Calcium supplementation
  • Eclampsia
  • Low-dose aspirin
  • Magnesium sulfate
  • Preeclampsia
  • Prevention

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Staff, A. C., Sibai, B. M., & Gary Cunningham, F. (2014). Prevention of preeclampsia and eclampsia. In Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition (pp. 253-267). Elsevier Science.